Results 11 to 20 of about 569,363 (269)
Mechanisms of stress in the brain [PDF]
Nature Neuroscience, 2015 The brain is the central organ involved in perceiving and adapting to social and physical stressors via multiple interacting mediators, from the cell surface to the cytoskeleton to epigenetic regulation and nongenomic mechanisms. A key result of stress is structural remodeling of neural architecture, which may be a sign of successful adaptation ...
Bruce S McEwen +6 more
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Understanding the mechanisms of lung mechanical stress [PDF]
Brazilian Journal of Medical and Biological Research, 2006 Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These
Garcia, C. S. N. B. +5 more
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Stress mechanisms in hypertension [PDF]
Postgraduate Medical Journal, 1986 Summary Recent studies of stress mechanisms in hypertension have focussed on the cardiovascular and neuroendocrine reactions to challenging or threatening psychosocial stimuli. Fixed hypertension may develop in some animal models following chronic exposure to psychosocial conflict.
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The Role of Mechanical Stresses in Angiogenesis [PDF]
Critical Reviews in Biomedical Engineering, 2005 Angiogenesis is the formation of new capillary blood vessels from preexisting vessels. It is involved in many normal and diseased conditions, as well as in the application of tissue-engineered products. There has been extensive effort made to develop strategies for controlling pathological angiogenesis and for promoting vascularization in biomedical ...
Yan-Ting, Shiu +5 more
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Destabilization of Indomethacin-Paracetamol Co-Amorphous Systems by Mechanical Stress
Pharmaceutics, 2023 Using co-amorphous systems (CAMS) has shown promise in addressing the challenges associated with poorly water-soluble drugs. Quench-cooling is a commonly used CAMS preparation method, often followed by grinding or milling to achieve a fine powder that is
Rong Di, Thomas Rades, Holger Grohganz
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Frontiers in Genetics, 2022 Background: Osteoarthritis (OA) is a common degenerative joint disease. The aims of this study are to explore the effects of mechanical stress on whole transcriptome landscape and to identify a non-coding transcriptome signature of mechanical stress ...
Jiaming Zhang +8 more
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Stress Mechanisms and Metabolic Complications
Hormone and Metabolic Research, 2007 Stress can be defined as a state of threatened homeostasis or disharmony. An intricate repertoire of physiologic and behavioral responses is mobilized under stressful situations forming the adaptive stress response that aims to reestablish the challenged body equilibrium. The hypothalamic-pituitary-adrenal axis and the central and peripheral components
Kyrou, I., Tsigos, C.
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Mechanism of Oxidative Stress in Neurodegeneration [PDF]
Oxidative Medicine and Cellular Longevity, 2012 Biological tissues require oxygen to meet their energetic demands. However, the consumption of oxygen also results in the generation of free radicals that may have damaging effects on cells. The brain is particularly vulnerable to the effects of reactive oxygen species due to its high demand for oxygen, and its abundance of highly peroxidisable ...
Gandhi, S, Abramov, AY
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Epigenetic mechanisms in stress and adaptation [PDF]
Brain, Behavior, and Immunity, 2011 Epigenetic mechanisms are processes at the level of the chromatin that control the expression of genes but their role in neuro-immuno-endocrine communication is poorly understood. This review focuses on epigenetic modifications induced by a range of stressors, both physical and psychological, and examines how these variations can affect the biological ...
Mifsud, Karen R +5 more
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Petroleum Exploration and Development, 2019 The differences of rock mechanical properties were analyzed based on triaxial compression test in low permeability reservoirs of the Bonan Oilfield. Through the analysis of reservoir mechanics, the influence mechanisms of different mechanical properties ...
Zhipeng LI +3 more
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