Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
LES of non-Newtonian physiological blood flow in a model of arterial stenosis [PDF]
Large Eddy Simulation (LES) is performed to study the physiological pulsatile transition-to-turbulent non-Newtonian blood flow through a 3D model of arterial stenosis by using five different blood viscosity models: (i) Power-law, (ii) Carreau, (iii ...
Ahmed+31 more
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
AMPLITUDE OF HEART RATE MODULATION WITH THE PERIOD OF\ud 3 CARDIOCYCLES DEPENDS ON THE PHYSIOLOGICAL AROUSAL OF THE BRAIN [PDF]
Amplitude of the 3-cardiocycle modulation of heart rate in records of 300 cardiointervals depends of the physiological arousal of brain. As arousal is a physiological component of stress, the amplitude of this heart rate modulation may be used as a ...
Mukhin, Dr Valery
core
Numerical analysis on the effect of normotensive and hypertensive physiological conditions onto hemodynamic characteristics in stented carotid artery [PDF]
An arterial re-blockage or restenosis by abnormal atherosclerosis and thrombosis progression in carotid artery is associated with the geometry of the implanted medical device, called as stent.
Ismail, Al Emran+3 more
core +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
Evaluating cognitive bias in clinical ethics supports: a scoping review
Background A variety of cognitive biases are known to compromise ethical deliberation and decision-making processes. However, little is known about their role in clinical ethics supports (CES).
Louise Giaume+4 more
doaj +1 more source
BackgroundPsychosocial well-being, which assesses emotional, psychological, social, and collective well-being, could help measure risk and duration of sick leave in workers.ObjectiveThis study aims to build a structural equation model of a psychosocial ...
Rémi Colin-Chevalier+5 more
doaj +1 more source
Identification of Resilient Individuals and Those at Risk for Performance Deficits under Stress
Human task performance is affected by exposure to physiological and psychological stress. The ability to measure the physiological response to stressors and correlate that to task performance could be used to identify resilient individuals or those at ...
Brent eWinslow+4 more
doaj +1 more source
More than a feeling: A unified view of stress measurement for population science. [PDF]
Stress can influence health throughout the lifespan, yet there is little agreement about what types and aspects of stress matter most for human health and disease.
Crosswell, Alexandra D+6 more
core +2 more sources