Results 81 to 90 of about 1,971,553 (284)

Protein changes as robust signatures of fish chronic stress: a proteomics approach to fish welfare research [PDF]

, 2020
Background Aquaculture is a fast-growing industry and therefore welfare and environmental impact have become of utmost importance. Preventing stress associated to common aquaculture practices and optimizing the fish stress response by ...
Cerqueira, Marco, Farinha, Ana Paula, Kuehn, Annette, Planchon, Sébastien, Raposo de Magalhães, Cláudia, Revets, Dominique, Rodrigues, Pedro, Schrama, Denise   +7 more
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Influence of prenatal maternal stress, maternal plasma cortisol and cortisol in the amniotic fluid on birth outcomes and child temperament at 3 months [PDF]

, 2004
This prospective, longitudinal study aimed to investigate relationships between indicators of maternal prenatal stress, infant birth outcomes and early temperament.
Baibazarova, Eugenia, van de Beek, Cornelieke, Cohen-Kettenis, Peggy T., Buitelaar, Jan, Shelton, Katherine Helen, Van Goozen, Stephanie Helena Maria   +5 more
core   +4 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Feedback Control of Human Stress with Music Modulation [PDF]

, 2020
Mental stress has known detrimental effects on human health, however few algorithmic methods of reducing mental stress have been widely explored. While the act of listening to music has been shown to have beneficial effects for stress reduction, and ...
Fu, Andrew
core  

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Estresse crônico melhora a função miocárdica sem alterar a atividade do canal-L para Ca+2 em ratos Chronic stress improves the myocardial function without altering L-type Ca+2 channel activity in rats

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: O estresse crônico está associado à remodelação cardíaca; entretanto, os mecanismos permanecem a ser descobertos. OBJETIVO: A proposta deste estudo foi testar a hipótese de que o estresse crônico promove disfunção cardíaca associada a ...
Thiago Bruder-Nascimento, Dijon Henrique Salome Campos, André Soares Leopoldo, Ana Paula Lima-Leopoldo, Katashi Okoshi, Sandra Cordellini, Antônio Carlos Cicogna   +6 more
doaj  

Neurological Soft Signs and Post-Traumatic Stress Disorder: A Biomarker of Severity?

Frontiers in Psychiatry, 2020
BackgroundThe psychophysiological changes for individual suffering from chronic post-traumatic stress disorder (PTSD) raise to the questions of how facilitate recovery and return to work.
Célia Belrose, Célia Belrose, Célia Belrose, Anais Duffaud, Anais Duffaud, Elsa Rakotoarison, Catherine Faget, Philippe Raynaud, Philippe Raynaud, Frédéric Dutheil, Frédéric Dutheil, Léa Boyer, Jean-Baptiste Billaud, Marion Trousselard, Marion Trousselard, Marion Trousselard   +15 more
doaj   +1 more source

Causes and Consequences of Physiological Stress of Women Involved in Tea Plucking Activity [PDF]

The present study was conducted in Kangra district of Himachal Pradesh (India) to study the physiological workload of respondents engaged in plucking tea leaves and identify the major causes and consequences of physiological stress.
Awasthi, Kumud, Kishtwaria, Jatinder, Lata, Suman, Rana, Aruna   +3 more
core   +1 more source