Results 91 to 100 of about 3,551,019 (296)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Regularity of three fields evolution of hydraulic fracturing process in coal seam
Gong-kuang zidonghua, 2016 Numerical simulation was conducted for hydraulic fracturing process in coal seam according to solid-liquid coupling equations and Mohr-Coulomb principle.
XU Zhaoyong +5 more
doaj +1 more source
Numerical study of the influence of seepage force on the stress field around a vertical wellbore
Engineering Applications of Computational Fluid Mechanics, 2020 Fluid seepage into rock pores not only generates poroelastic stress but also exerts seepage force on the rock skeleton. However, since the mechanism of the effect of seepage force on the stress field around the wellbore is not clear, conventional methods
Desheng Zhou +7 more
doaj +1 more source
Immersed boundary method predictions of shear stresses for different flow topologies occuring in cerebral aneurysms [PDF]
, 2010 A volume-penalizing immersed boundary method is presented that facilitates the computation of incompressible fluid flow in complex flow domains. We apply this method to simulate the flow in cerebral aneurysms, and focus on the accuracy with which the ...
Geurts, Bernard J. +3 more
core +1 more source
On the Granular Stress-Geometry Equation
, 2014 Using discrete calculus, we derive the missing stress-geometry equation for rigid granular materials in two dimensions, in the mean-field approximation. We show that (i) the equation imposes that the voids cannot carry stress, (ii) stress transmission is
DeGiuli, Eric, Schoof, Christian
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Determining the stress field in active volcanoes using focal mechanisms
Frontiers in Earth Science, 2016 Stress inversion of seismological datasets became an essential tool to retrieve the stress field of active tectonics and volcanic areas. In particular, in volcanic areas, it is able to put constrains on volcano-tectonics and in general in a better ...
Bruno Massa +5 more
doaj +1 more source
Ultrasonic measurement of stress in 2219-T87 aluminum plate [PDF]
The basic relationship of ultrasonic signal velocity to directional subsurface stress is reviewed. Inappropriateness of dependency on a single correlative value of constant for a three dimensional stress field in metallic materials is discussed ...
Clotfelter, W. N., Risch, E. R.
core +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source