Results 91 to 100 of about 3,588,860 (347)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Earthquake ScienceIn this study, the shear-wave splitting parameters of local seismic events from the source regions of the 2023 Türkiye MW7.7 and MW7.6 doublet earthquakes (event 1 and event 2, respectively) were measured from June 1, 2022, to April 25, 2023, and their ...
Xuelai Cao, Lijun Chang
doaj +1 more source
Геодинамика и тектонофизика, 2015 In the Earth's lithosphere, wavy alternation of positive and negative heterochronous structures is revealed; such structures are variable in ranks and separated by vergence zones of fractures and folds.
Tatiana Yu. Tveretinova
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The Journal of Engineering, 2015 Laser Shock Peening is a fatigue enhancement treatment using laser energy to induce compressive Residual Stresses (RS) in the outer layers of metallic components.
M. Sticchi +7 more
doaj +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Stress Intensity Factor of Mode III Cracks in Thin Sheets
, 2010 The stress field at the tip of a crack of a thin plate of elastic material that is broken due to a mode III shear tearing has a universal form with a non-universal amplitude, known as the stress intensity factor, which depends on the crack length and the
Cohen, Yossi, Procaccia, Itamar
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Regularity of three fields evolution of hydraulic fracturing process in coal seam
Gong-kuang zidonghua, 2016 Numerical simulation was conducted for hydraulic fracturing process in coal seam according to solid-liquid coupling equations and Mohr-Coulomb principle.
XU Zhaoyong +5 more
doaj +1 more source