Results 101 to 110 of about 3,588,860 (347)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Research on Analytical Solution of Stress Fields in Adjacent Tunnel Surrounding Rock Under Blasting and Verification Analysis

Applied Sciences
In tunnel blasting, an analytical solution for dynamic stress in the surrounding rock of adjacent tunnels is critical for dynamic response analysis, mechanical evaluations, and crack propagation control.
Tao Luo, Yong Wei, Junbo Zhao, Yelong Xie, Yan Hu, Xiaoming Lou, Xiaofeng Huo   +6 more
doaj   +1 more source

Determining the stress field in active volcanoes using focal mechanisms

Frontiers in Earth Science, 2016
Stress inversion of seismological datasets became an essential tool to retrieve the stress field of active tectonics and volcanic areas. In particular, in volcanic areas, it is able to put constrains on volcano-tectonics and in general in a better ...
Bruno Massa, Bruno Massa, Luca D'Auria, Luca D'Auria, Elena Cristiano, Ada De Matteo   +5 more
doaj   +1 more source

Ultrasonic measurement of stress in 2219-T87 aluminum plate [PDF]

The basic relationship of ultrasonic signal velocity to directional subsurface stress is reviewed. Inappropriateness of dependency on a single correlative value of constant for a three dimensional stress field in metallic materials is discussed ...
Clotfelter, W. N., Risch, E. R.
core   +1 more source

Thermal divergences on the event horizons of two-dimensional black holes

, 1995
The expectation value of the stress-energy tensor $\langleT_{\mu\nu}\rangle$ of a free conformally invariant scalar field is computed in a general static two-dimensional black hole spacetime when the field is in either a zero temperature vacuum state or ...
B. S. Kay, C. F. E. Holzhey, C. G. Callan, C. W. Misner, D. Garfinkle, D. Garfinkle, D. Hochberg, D. Markovic, Daniel J. Loranz, G. W. Gibbons, G. W. Gibbons, H. F. Dowker, J. A. Harvey, J. W. York, Jr., K. W. Howard, K. W. Howard, M. J. Duff, P. C. W. Davies, P. R. Anderson, P. R. Anderson, P. R. Anderson, P. R. Anderson, Paul R. Anderson, S. M. Christensen, S. Trivedi, S. W. Hawking, William A. Hiscock   +26 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Surrogate modelling of thermal and residual stress fields in cold-spray additive manufacturing using machine learning

Virtual and Physical Prototyping
In cold spray additive manufacturing, temperature and residual stress evolution significantly affect product quality and service life. Conventional finite element (FE) simulations provide predictions but are computationally expensive for large-scale ...
Chunyang Xia, Scott Julien, Salih Duran, Elizabeth Chang-Davidson, Santanu Paul, Sinan Müftü   +5 more
doaj   +1 more source

Hyper-stresses in k $k$ -Jet Field Theories

Journal of Elasticity, 2018
For high-order continuum mechanics and classical field theories configurations are modeled as sections of general fiber bundles and generalized velocities are modeled as variations thereof. Smooth stress fields are considered and it is shown that three distinct mathematical stress objects play the roles of the traditional stress tensor of continuum ...
Reuven Segev, Jędrzej Śniatycki
openaire   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Architecture of the upper crust along the WARR deep seismic profile SHIELD’21 across Ukraine based on seismic and geological data

Геофизический журнал
For the first time a seismic image of the East-European Craton upper crust between the Carpathians and the Dnieper-Donets Basin is presented, based on the finite-difference reflection/refraction migration processing of the SHIELD’21 deep profile results
A.V. Murovska, O.O. Verpakhovska, V.I. Starostenko, T.P. Yegorova, T. Janik, P. Aleksandrowski, S.V. Mychak, V.I. Alokhin   +7 more
doaj   +1 more source