Results 71 to 80 of about 3,588,860 (347)
Deep Underground Science and EngineeringGeothermal energy has gained wide attention as a renewable alternative for mitigating greenhouse gas emissions. The advancements in enhanced geothermal system technology have enabled the exploitation of previously inaccessible geothermal resources ...
Xinghui Wu +5 more
doaj +1 more source
地质科技通报Objective The Sikeshu Sag of the southern Junggar Basin is tectonically located in the western thrust belt of the North Tianshan Mountains. The basin has undergone multiple stages and multidirectional tectonic movements since the Palaeozoic.
Honghui GUO +5 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Stress-Energy Tensor of the Quantized Massive Fields in Friedman-Robertson-Walker Spacetimes
, 2013 The approximate stress-energy tensor of the quantized massive scalar, spinor and vector fields in the spatially flat Friedman-Robertson-Walker universe is constructed.
Matyjasek, Jerzy, Sadurski, Paweł
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On the Granular Stress-Geometry Equation
, 2014 Using discrete calculus, we derive the missing stress-geometry equation for rigid granular materials in two dimensions, in the mean-field approximation. We show that (i) the equation imposes that the voids cannot carry stress, (ii) stress transmission is
DeGiuli, Eric, Schoof, Christian
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source