Results 71 to 80 of about 3,551,019 (296)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 1999 Two novel phenomena in a weakly coupled granular superconductor under an applied stress are predicted which are based on recently suggested piezophase effect (a macroscopic quantum analog of the piezoelectric effect) in mechanically loaded grain boundary
A. H. Cottrell +15 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Геофизический журнал, 2018 Recent stress fields at the northern margin of the Black Sea have been characterized on the base of 32 mechanisms of the earthquakes foci. Orientations of compression axes in the foci give evidence that present-day tectonic process takes place under ...
A. Murovskaya +3 more
doaj +1 more source
Thermal divergences on the event horizons of two-dimensional black holes
, 1995 The expectation value of the stress-energy tensor $\langleT_{\mu\nu}\rangle$ of a free conformally invariant scalar field is computed in a general static two-dimensional black hole spacetime when the field is in either a zero temperature vacuum state or ...
B. S. Kay +26 more
core +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Dizhen xuebao, 2019 利用区域应力张量阻尼方法，使用南北地震带及其邻近区域2009年1月—2017年8月466次ML≥3.5地震的震源机制解，及1976年1月—2017年8月GCMT公布的259次M≥4.5地震的震源机制解，反演得到研究区1.0°×1.0°网格大小区域的构造应力场。应力场空间分布特征显示，南北地震带作为青藏高原的东边界，由于所处动力环境复杂，其内部最大主应力方向具有明显的空间差异性。这种差异主要表现为：南北地震带北段最大主应力方向为NE向；南北地震带中段及周边除龙门山断裂带NE段最大主应力为NW-NNW向外 ...
Zijian Cui +3 more
doaj +1 more source