Results 121 to 130 of about 4,657,064 (329)

NEDDylation promotes stress granule assembly

Nature Communications, 2016
Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in response to
Aravinth Kumar Jayabalan, Anthony Sanchez, Ra Young Park, Sang Pil Yoon, Gum-Yong Kang, Je-Hyun Baek, Paul Anderson, Younghoon Kee, Takbum Ohn   +8 more
doaj   +1 more source

The Myoblast C2C12 Transfected with Mutant Valosin-Containing Protein Exhibits Delayed Stress Granule Resolution on Oxidative Stress. [PDF]

, 2016
Valosin-containing protein (VCP) mutations cause inclusion body myopathy with Paget disease and frontotemporal dementia. However, the mechanisms by which mutant VCP triggers degeneration remain unknown.
Kitazawa, Masashi, Kimonis, Virginia E, Tran, Diana N, Rodriguez-Ortiz, Carlos J, Flores, Julio C, Rodriguez, Gema J, Valenzuela, Joanna A, Zumkehr, Joannee   +7 more
core   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Large-scale purifications reveal yeast and human stress granule cores are heterogeneous particles with complex transcriptomes and proteomes

Cell Reports
Summary: Stress granules are a conserved response of eukaryotic cells to environmental insults. These cytoplasmic ribonucleoprotein condensates have hitherto been primarily studied by microscopy, which showed previously that they comprise dense ∼200 nm ...
Natalia A. Demeshkina, Adrian R. Ferré-D’Amaré   +1 more
doaj   +1 more source

Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.

PLoS ONE, 2012
The FET family of proteins is composed of FUS/TLS, EWS/EWSR1, and TAF15 and possesses RNA- and DNA-binding capacities. The FET-proteins are involved in transcriptional regulation and RNA processing, and FET-gene deregulation is associated with ...
Jenny Blechingberg, Yonglun Luo, Lars Bolund, Christian Kroun Damgaard, Anders Lade Nielsen   +4 more
doaj   +1 more source

Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

bioRxiv, 2020
Cytoplasmic stress granules (SG) form in response to a variety of cellular stresses by phase-separation of proteins associated with non-translating mRNAs.
Hagai Marmor-Kollet, Aviad Siany, N. Kedersha, Naama Knafo, Natalia Rivkin, Yehuda M. Danino, T. Olender, Nir Cohen, T. Moens, A. Higginbottom, John Cooper- Knock, Chen Eitan, B. Cohen, L. Van Den Bosch, P. Anderson, P. Ivanov, T. Geiger, E. Hornstein   +17 more
semanticscholar   +1 more source

Chronic stress antagonizes formation of stress granules

iScience
Abstract Chronic stress mediates cellular changes that can contribute to human disease. However, fluctuations in RNA metabolism caused by chronic stress have been largely neglected in the field. Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and ...
Yuichiro Adachi, Allison M. Williams, Masashi Masuda, Yutaka Taketani, Paul J. Anderson, Pavel Ivanov   +5 more
openaire   +3 more sources

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Distinct features of stress granule proteins predict localization in membraneless organelle.

Journal of Molecular Biology, 2020
Recently generated proteomic data provides unprecedented insight into stress granule composition and stands as fruitful ground for further analysis. Stress granules are stress-induced biological assemblies that are of keen interest due to being linked to
Erich R. Kuechler, P. Budzyńska, Jonathan P. Bernardini, Jörg Gsponer, T. Mayor   +4 more
semanticscholar   +1 more source

A Comparative Analysis of Stress Granule Assembly in Replicative and Stress-Induced Premature Senescence [PDF]

, 2016
It has been well-established that primary human cells possess a limited proliferative capacity, undergoing an irreversible cell cycle arrest after a set number of population doublings known as replicative senescence.
PLYGAWKO, ANDREW,THOMAS
core