Results 141 to 150 of about 128,882 (297)

Fission yeast Caprin protein is required for efficient heterochromatin establishment.

PLoS Genetics
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Haidao Zhang, Ekaterina Kapitonova, Adriana Orrego, Christos Spanos, Joanna Strachan, Elizabeth H Bayne   +5 more
doaj   +1 more source

Elastomers Combining Damping Efficiency With Rapid Recovery

Advanced Materials Technologies, EarlyView.
Double network granular elastomers (DNGEs) combine high energy dissipation under both cyclic loading and high impact with rapid shape recovery. 3D printing enables the production of complex, customizable structures with tailored performance. Recyclable DNGEs retain their properties over multiple recycling cycles.
Eva Baur, Alain Molleyres, Esther Amstad
wiley   +1 more source

Establishment of a stress granule reporter system for evaluating in vitro colon toxicity

Animal Cells and Systems
Exposure to toxic molecules from food or oral medications induces toxicity in colon cells that cause various human diseases; however, in vitro monitoring systems for colon cell toxicity are not well established.
Namjoon Cho, Da-Min Jung, Eun-Mi Kim, Kee K. Kim   +3 more
doaj   +1 more source

Magnetic flux emergence in granular convection: Radiative MHD simulations and observational signatures

, 2007
We study the emergence of magnetic flux from the near-surface layers of the solar convection zone into the photosphere. To model magnetic flux emergence, we carried out a set of numerical radiative magnetohydrodynamics simulations.
Abbett, Abbett, Archontis, Archontis, Born, Brants, Caligari, Caligari, Cheung, Cheung, D'Silva, De Pontieu, Deinzer, Domínguez Cerdeña, Dorch, Emonet, F. Moreno-Insertis, Fan, Fan, Fan, Fan, Fan, Fan, Forbes, Galsgaard, Grossmann-Doerth, Grossmann-Doerth, Hagenaar, Hagenaar, Hurlburt, Ichimoto, Isobe, Kubo, Leake, Lites, Lites, Longcope, M. C. M. Cheung, M. Schüssler, Magara, Magara, Magara, Moreno-Insertis, Moreno-Insertis, Murray, Nordlund, Pariat, Parker, Parker, Proctor, Roberts, Schüssler, Schüssler, Shibata, Solanki, Spruit, Spruit, Stein, Stein, Stein, Steiner, Strous, Title, Tobias, Török, Venkatakrishnan, Vögler, Weiss, Zirin, Zwaan, Zwaan, Zwaan   +71 more
core   +1 more source

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

Advanced Science, EarlyView.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su, Ting‐Chun Chou, Maria Teresa López‐Cascales, Junfeng Huang, Tsai‐Ying Chen, Sjoukje van Wieren, Chan Li, Cecile Beerens, Li You, Jelle Storteboom, Miao‐Ping Chien   +10 more
wiley   +1 more source

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

Cell Reports
Summary: G3BP1/2 are paralogous proteins that promote stress granule formation in response to cellular stresses, including viral infection. The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibits stress ...
Zemin Yang, Bryan A. Johnson, Victoria A. Meliopoulos, Xiaohui Ju, Peipei Zhang, Michael P. Hughes, Jinjun Wu, Kaitlin P. Koreski, Jemma E. Clary, Ti-Cheng Chang, Gang Wu, Jeff Hixon, Jay Duffner, Kathy Wong, Rene Lemieux, Kumari G. Lokugamage, R. Elias Alvarado, Patricia A. Crocquet-Valdes, David H. Walker, Kenneth S. Plante, Jessica A. Plante, Scott C. Weaver, Hong Joo Kim, Rachel Meyers, Stacey Schultz-Cherry, Qiang Ding, Vineet D. Menachery, J. Paul Taylor   +27 more
doaj   +1 more source

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source