Results 161 to 170 of about 4,657,064 (329)
UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation
Advanced Science, EarlyView.ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro +7 more
wiley +1 more source
Fission yeast Caprin protein is required for efficient heterochromatin establishment.
PLoS GeneticsHeterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Haidao Zhang +5 more
doaj +1 more source
Properties of Stress Granule and P-Body Proteomes.
Molecules and Cells, 2019 Stress granules and P-bodies are cytosolic biomolecular condensates that dynamically form by the phase separation of RNAs and proteins. They participate in translational control and buffer the proteome.
J. Youn +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao +14 more
wiley +1 more source
Establishment of a stress granule reporter system for evaluating in vitro colon toxicity
Animal Cells and SystemsExposure to toxic molecules from food or oral medications induces toxicity in colon cells that cause various human diseases; however, in vitro monitoring systems for colon cell toxicity are not well established.
Namjoon Cho +3 more
doaj +1 more source
eLife, 2015 RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein aggregates or through phase separation into a liquid RNA/protein phase. Which model describes RNP granules in living cells is still unclear.
Sonja Kroschwald +7 more
doaj +1 more source
, 2020 Presentation of poster 1891A at TAGC 2020 online. Files include a PDF of the poster (Determining the effects of Pab1 acetylation at K131 on stress granule dynamics in Saccharomyces cerevisiae.pdf) and a 7-minute video walkthrough of the poster material ...
Sylvain Huard (3775999) +2 more
core +1 more source
Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
eLifeWe report a minimally disruptive labeling strategy for stress granule protein, G3BP Stress Granule Assembly Factor 1 (G3BP1), and ALS-linked protein, TAR DNA-binding protein 43 (TDP-43), using the fluorescent non-canonical amino acid Anap. By integrating
Hao Chen +6 more
doaj +1 more source
Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation
eLife, 2015 T follicular helper cells (Tfh) are critical for the longevity and quality of antibody-mediated protection against infection. Yet few signaling pathways have been identified to be unique solely to Tfh development.
Roybel R Ramiscal +17 more
doaj +1 more source