Results 61 to 70 of about 70,206 (162)
Pathological stress granules in Alzheimer’s disease [PDF]
Brain Research, 2014 A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins.
Peter E A, Ash +4 more
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Molecular Neurobiology, 2016 Hexanucleotide repeat expansions in the C9ORF72 gene are causally associated with frontotemporal lobar dementia (FTLD) and/or amyotrophic lateral sclerosis (ALS). The physiological function of the normal C9ORF72 protein remains unclear. In this study, we characterized the subcellular localization of C9ORF72 to processing bodies (P-bodies) and its ...
Niran Maharjan +3 more
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RNP Granule Formation: Lessons from P-Bodies and Stress Granules [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2019 It is now clear that cells form a wide collection of large RNA-protein assemblies, referred to as RNP granules. RNP granules exist in bacterial cells and can be found in both the cytosol and nucleus of eukaryotic cells. Recent approaches have begun to define the RNA and protein composition of a number of RNP granules.
Giulia Ada, Corbet, Roy, Parker
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RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome [PDF]
Proceedings of the National Academy of Sciences, 2018 Significance Stress granules, which are ubiquitous, non–membrane-bound assemblies of protein and RNA, form when translation initiation is inhibited, contribute to the regulation of gene expression, and are implicated in the pathologies of cancer and neurodegenerative disease. Understanding the mechanisms of stress
Briana, Van Treeck +5 more
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Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics [PDF]
Journal of Neuroscience, 2014 Mutations in the PFN1 gene encoding profilin 1 are a rare cause of familial amyotrophic lateral sclerosis (ALS). Profilin 1 is a well studied actin-binding protein but how PFN1 mutations cause ALS is unknown. The budding yeast, Saccharomyces cerevisiae, has one PFN1 ortholog.
Matthew D, Figley +4 more
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P-body and Stress Granule Quantification in Caenorhabditis elegans
Bio-Protocol, 2017 Eukaryotic cells contain various types of cytoplasmic, non-membrane bound ribonucleoprotein (RNP) granules that consist of non-translating mRNAs and a versatile set of associated proteins. One prominent type of RNP granules is Processing bodies (P bodies)
Matthias Rieckher +1 more
doaj +1 more source
PLoS Pathogens, 2020 Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use of ...
Michèle Brocard +11 more
doaj +1 more source
A switch for stress granule assembly [PDF]
Journal of Cell Biology, 2016 ![Figure][1] Cells overexpressing USP10 (green) fail to form stress granules (magenta) when translation initiation is inhibited. [Kedersha et al.][2] describe how phosphorylation and the competition between mutually exclusive binding partners regulate G3BP’s ability to mediate ...
openaire +2 more sources
Nature Communications, 2017 Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz +5 more
doaj +1 more source
Microbial CellVarious stress conditions, such as heat stress (HS) and oxidative stress, can cause biomolecular condensates represented by stress granules (SGs) via liquid-liquid phase separation.
Naofumi Tomimoto +2 more
doaj +1 more source