Results 61 to 70 of about 1,437,569 (357)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Evaluasi Faktor Intensitas Tegangan Pada Ujung Retak Dengan Lubang Penghambar Rambat Petak [PDF]

, 2010
The evaluation of stress intensity factors in the crack tip interacting with stoping hole of crack growth was conducted by computer simulation, and this was carried out on vareid configuration of stopping hole. The results of the simulation show that the
Purnowidodo, A. (Anindito)
core  

Injustice perceptions about pain: parent–child discordance is associated with worse functional outcomes [PDF]

, 2018
Pain is experienced within and influenced by social environments. For children with chronic pain, the child–parent relationship and parental beliefs about pain are particularly important and may influence pain outcomes. Pain-related injustice perceptions
Hirsh, Adam T., Miller, Megan M., Scott, Eric L., Trost, Zina, Williams, Amy E., Wuest, David   +5 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]

The stress intensity factor is determined for a cracked orthotropic sheet adhesively bonded to an orthotropic stringer. Since the stringer is modeled as a semiinfinite sheet, the solution is most appropriate for a crack tip located near a stringer edge ...
Bigelow, C. A.
core   +1 more source

Crack path selection at the interface of wrought and wire+arc additive manufactured Ti–6Al–4V [PDF]

, 2016
Crack propagation deviation tendency in specimens containing an interface between wrought alloy substrate and Wire + Arc Additive Manufacture (WAAM) built Ti–6Al–4V is investigated from the viewpoints of microstructure, residual stress and bi-material ...
Addison, Antonysamy, Antonysamy, ASTM, Baufeld, Baufeld, Brandl, Brandl, Colegrove, Dahlin, Dattoma, Ding, Edwards, Edwards, Edwards, Evans, Fan, Frazier, Hills, Irwin, Kelly, Leuders, Lorant, Martina, Mok, Nègre, Paradowska, Peters, Pippan, Prime, Prime, Rangaswamy, Schroeder, Taminger, Van Hooreweder, Wang, Wang, Zhang, Zhang, Zhu   +39 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fracture parameters formulation for single edge notched AS4 stitched warp-knit fabric composite plate [PDF]

, 2019
The three-dimensional problem of the fracture for the single edge notched tension plate (SENT) of orthotropic material is considered in this paper. The finite element solution is used to evaluate the singular and non-singular terms of the William series,
DJEBLI, Abdelkader, LALLAM, Mostefa, MAMOURI, Said   +2 more
core   +2 more sources

Numerical Calculation of Stress Intensity Factor of Tooth Root Crack in the High-speed EMU Gear

Jixie chuandong, 2017
In order to research the stress intensity factor of tooth root of the high-speed EMU gear,the location of crack initiation is determined by combining the finite element method and mapping method.
Li Xiuhong, Wang Yubin, Li Wenhui, Qin Xiaofeng, Pang Yinming   +4 more
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