Results 61 to 70 of about 1,437,001 (231)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
STRESS INTENSITY FACTOR FOR CRACKED FLAT-ELLIPTIC CROSS-SECTION PIPE
Jixie qiangdu, 2017 As an important parameter to assess the crack pipe fracture toughness,stress intensity factor determined is particularly important. In order to solve practical engineering problems,most of them are three-dimensional crack problems,crack mouth widening ...
LI Chong, XIE YuJun
doaj
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Evaluation of stress intensity factor for small edge interface crack under thermal stress
Nihon Kikai Gakkai ronbunshu, 2015 This paper deals with the analysis of the thermal stress intensity factor for small edge interfacial crack between bonded dissimilar plates subjected to uniform change of temperature by using the crack tip stress method.
Kazuhiro ODA +3 more
doaj +1 more source
Thermal activation of rupture and slow crack growth in a model of homogenous brittle materials [PDF]
, 2003 Slow crack growth in a model of homogenous brittle elastic material is described as a thermal activation process where stress fluctuations allow to overcome a breaking threshold through a series of irreversible steps.
Diu B. +6 more
core +5 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
STUDY ON STRESS INTENSITY FACTOR OF THREE DIMENSION MODEL OF TYPEⅠCRACK IN TYPICAL LUG JOINT
Jixie qiangdu, 2018 On the basis of two-dimension finite element analysis,the two-dimension stress intensity factor correction coefficients of typical lug joint were obtained; Three dimension elastic plastic contact finite element model of the typical lug joint was ...
WANG XinBo +4 more
doaj
Study of the stress intensity factors in the bulk of the material with synchrotron diffraction [PDF]
, 2017 Artículo de Proceedings de Congreso Internacional Fatigue2017In this work we present the results of a hybrid experimental and analytical approach for estimating the stress intensity factor.
Buslaps, T +5 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source