Results 71 to 80 of about 1,437,001 (231)
A cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]
The stress intensity factor is determined for a cracked orthotropic sheet adhesively bonded to an orthotropic stringer. Since the stringer is modeled as a semiinfinite sheet, the solution is most appropriate for a crack tip located near a stringer edge ...
Bigelow, C. A.
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Stress intensity factor in a tapered specimen [PDF]
The general problem of a tapered specimen containing an edge crack is formulated in terms of a system of singular integral equations. The equations are solved and the stress intensity factor is calculated for a compact and for a slender tapered specimen,
Erdogan, F., Xue-Hui, L.
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Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Numerical Calculation of Stress Intensity Factor of Tooth Root Crack in the High-speed EMU Gear
Jixie chuandong, 2017 In order to research the stress intensity factor of tooth root of the high-speed EMU gear,the location of crack initiation is determined by combining the finite element method and mapping method.
Li Xiuhong +4 more
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Fracture study of windshield glass panes [PDF]
The major stresses which cause crack propagation in windshield glass panes are induced by bending moments which result from the pressure differentials across the panes.
Yeh, H. Y.
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Evaluasi Faktor Intensitas Tegangan Pada Ujung Retak Dengan Lubang Penghambar Rambat Petak [PDF]
, 2010 The evaluation of stress intensity factors in the crack tip interacting with stoping hole of crack growth was conducted by computer simulation, and this was carried out on vareid configuration of stopping hole. The results of the simulation show that the
Purnowidodo, A. (Anindito)
core
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Effect of debond growth on stress-intensity factors in a cracked orthotropic sheet stiffened by a semi-infinite orthotropic sheet [PDF]
Stress-intensity factors are determined for a cracked infinite sheet adhesively bonded to a stringer, and debonding of the adhesive layer is predicted. The stringer is modeled as a semi-infinite sheet. Adhesive nonlinearity is also included.
Bigelow, C. A.
core +1 more source