Results 91 to 100 of about 325,395 (379)

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Metabotropic Glutamate Receptor 5 Antagonism Reduces Pathology and Differentially Improves Symptoms in Male and Female Heterozygous zQ175 Huntington’s Mice

Frontiers in Molecular Neuroscience, 2022
Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disorder that leads to progressive motor and cognitive impairment. There are currently no available disease modifying treatments for HD patients. We have previously shown that
Si Han Li, Si Han Li, Tash-Lynn L. Colson, Tash-Lynn L. Colson, Khaled S. Abd-Elrahman, Khaled S. Abd-Elrahman, Khaled S. Abd-Elrahman, Stephen S. G. Ferguson, Stephen S. G. Ferguson   +8 more
doaj   +1 more source

Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome [PDF]

, 2019
Psychosis has been proposed to develop from dysfunction in a hippocampal-striatal-midbrain circuit, leading to aberrant salience processing. Here, we used functional magnetic resonance imaging (fMRI) during novelty salience processing to investigate this
Allen, P. M., Antoniades, M., Azis, M., Bonoldi, I., Bossong, M. G., Broome, M. R., Dima, D., Gifford, G. W. G., Grace, A. A., Howes, O. D., McGuire, P., Modinos, G., Perez, J., Quinn, B., Samson, C., Smart, S. E., Stone, J. M., Zugman, A.   +17 more
core   +8 more sources

Canoptum striatum

, 2020
Published as part of Tekin, Kagan, Krystyn, Leopold, Okuyucu, Cengiz, Bedi, Yavuz & Sayit, Kaan, 2020, Late Triassic to Early Jurassic radiolarian, conodont and ammonite assemblages from the Tavuscayiri block, Mersin Mélange, southern Turkey: Time constraints for the T / J boundary and sedimentary evolution of the southern margin of the northern ...
Tekin, Kagan, Krystyn, Leopold, Okuyucu, Cengiz, Bedi, Yavuz, Sayit, Kaan   +4 more
openaire   +2 more sources

The role of the striatum in social behavior [PDF]

Frontiers in Neuroscience, 2013
Where and how does the brain code reward during social behavior? Almost all elements of the brain's reward circuit are modulated during social behavior. The striatum in particular is activated by rewards in social situations. However, its role in social behavior is still poorly understood.
Raymundo Býez-Mendoza, Wolfram Schultz
openaire   +4 more sources

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Nuclear neurotransmitter molecular imaging of autism spectrum disorder

AIMS Molecular Science, 2019
Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by marked deficits in social communication and interaction, including limited and repetitive patterns of behavior.
Alveena Batool Syed, James Robert Brašić   +1 more
doaj   +1 more source

NINscope, a versatile miniscope for multi-region circuit investigations

eLife, 2020
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor neural signals during unrestrained behavior and their open-source versions have made them affordable.
Andres de Groot, Bastijn JG van den Boom, Romano M van Genderen, Joris Coppens, John van Veldhuijzen, Joop Bos, Hugo Hoedemaker, Mario Negrello, Ingo Willuhn, Chris I De Zeeuw, Tycho M Hoogland   +10 more
doaj   +1 more source

Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital

Scientific Reports, 2017
Corynebacterium striatum is a nosocomial opportunistic pathogen increasingly associated with a wide range of human infections and is often resistant to several antibiotics. We investigated the susceptibility of 63 C.
S. Alibi, A. Ferjani, J. Boukadida, M. E. Cano, Marta Fernández-Martínez, L. Martínez-Martínez, J. Navas   +6 more
semanticscholar   +1 more source

Multisensory Integration in the Mouse Striatum [PDF]

Neuron, 2014
The basal ganglia are involved in sensorimotor functions and action selection, both of which require the integration of sensory information. In order to determine how such sensory inputs are integrated, we obtained whole-cell recordings in mouse dorsal striatum during presentation of tactile and visual stimuli.
Ramon Reig, Gilad Silberberg
openaire   +4 more sources