Results 141 to 150 of about 325,395 (379)
Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies
Annals of Neurology, EarlyView.Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat +17 more
wiley +1 more source
Predicting Progression in Parkinson's Disease Using Baseline and 1-Year Change Measures. [PDF]
, 2019 BackgroundImproved prediction of Parkinson's disease (PD) progression is needed to support clinical decision-making and to accelerate research trials.ObjectivesTo examine whether baseline measures and their 1-year change predict longer-term progression ...
Arnedo, Vanessa +15 more
core +1 more source
Cerebral Cortex, 2014 The striatum acts in conjunction with the cortex to control and execute functions that are impaired by abnormal dopamine neurotransmission in disorders such as Parkinson's and schizophrenia.
A. Tziortzi +11 more
semanticscholar +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves +3 more
wiley +1 more source
Journal of Neuroscience, 2015 Context-induced reinstatement of drug seeking is a well established animal model for assessing the neural mechanisms underlying context-induced drug relapse, a major factor in human drug addiction. Neural activity in striatum has previously been shown to
Rubio Fj +12 more
semanticscholar +1 more source
Chemistry &Biodiversity, EarlyView.ABSTRACT A halogenated symmetrical formamidine, N,N′‐bis(3‐chloro‐4‐fluorophenyl)formamidine (FCF) was synthesized by the condensation reaction between triethyl orthoformate and 3‐chloro‐4‐fluoroaniline in 1:2 ratio. The compound FCF was characterized by FT‐IR, mass, NMR (1H and 13C) spectroscopic techniques and the purity was confirmed by elemental ...
Segun D. Oladipo +6 more
wiley +1 more source
Journal of Neuroscience, 2014 Cholinergic transmission in the striatal complex is critical for the modulation of the activity of local microcircuits and dopamine release. Release of acetylcholine has been considered to originate exclusively from a subtype of striatal interneuron that
Daniel Dautan +7 more
semanticscholar +1 more source
Manganese Neurotoxicity and Familial Disorders of Manganese Transport
Annals of the Child Neurology Society, EarlyView.ABSTRACT Manganese is the 12th most common element in the Earth's crust and is an essential industrial component. Biologically, this metal plays an important role as a constituent of numerous enzymes. While manganese is required for normal biochemical and physiological processes, manganese excess can lead to significant toxicity, particularly to the ...
Sidney M. Gospe Jr.
wiley +1 more source
A Brain Motivated to Play: Insights into the Neurobiology of Playfulness
, 2016 Play is an important part of normal childhood development and is seen in varied forms among many mammals. While not indispensable to normal development, playful social experiences as juveniles may provide an opportunity to develop flexible behavioural ...
Siviy, Stephen M.
core +1 more source
Biofilm production by multiresistant Corynebacterium striatum associated with nosocomial outbreak
Memórias do Instituto Oswaldo Cruz, 2015 Corynebacterium striatum is a potentially pathogenic microorganism that causes nosocomial outbreaks. However, little is known about its virulence factors that may contribute to healthcare-associated infections (HAIs).
Cassius de Souza +9 more
semanticscholar +1 more source