Results 51 to 60 of about 278,206 (253)

Noise exposure in early adulthood causes age-dependent and brain region-specific impairments in cognitive function

Frontiers in Neuroscience, 2022
Hearing loss is a chronic health condition that affects millions of people worldwide. In addition to age-related hearing impairment, excessive noise exposure is a leading cause of hearing loss. Beyond the devastating effects of hearing impairment itself,
Salonee V. Patel, Courtney M. DeCarlo, Shae A. Book, Ashley L. Schormans, Shawn N. Whitehead, Brian L. Allman, Sarah H. Hayes   +6 more
doaj   +1 more source

Logarithmic distributions prove that intrinsic learning is Hebbian

, 2017
In this paper, we present data for the lognormal distributions of spike rates, synaptic weights and intrinsic excitability (gain) for neurons in various brain areas, such as auditory or visual cortex, hippocampus, cerebellum, striatum, midbrain nuclei ...
Scheler, Gabriele
core   +2 more sources

Motor Areas Show Altered Dendritic Structure in an Amyotrophic Lateral Sclerosis Mouse Model

Frontiers in Neuroscience, 2017
Objective: Motor neurons (MNs) die in amyotrophic lateral sclerosis (ALS), a clinically heterogeneous neurodegenerative disease of unknown etiology. In human or rodent studies, MN loss is preceded by increased excitability.
Matthew J. Fogarty, Erica W. H. Mu, Nickolas A. Lavidis, Peter G. Noakes, Peter G. Noakes, Mark C. Bellingham   +5 more
doaj   +1 more source

Dopamine D1 and Glutamate Receptors Co-operate With Brain-Derived Neurotrophic Factor (BDNF) and TrkB to Modulate ERK Signaling in Adult Striatal Slices

Frontiers in Cellular Neuroscience, 2020
In the striatum, the input nucleus of the basal ganglia, the extracellular-signal-regulated kinase (ERK) pathway, necessary for various forms of behavioral plasticity, is triggered by the combined engagement of dopamine D1 and ionotropic glutamate ...
Ilaria Morella, Ilaria Morella, Harriet Hallum, Harriet Hallum, Riccardo Brambilla, Riccardo Brambilla   +5 more
doaj   +1 more source

Genetic tagging of the adenosine A2A receptor reveals its heterogeneous expression in brain regions

Frontiers in Neuroanatomy, 2022
The adenosine A2A receptor (A2AR), a G protein-coupled receptor, is involved in numerous and varied physiological and pathological processes, including inflammation, immune responses, blood flow, and neurotransmission.
Muran Wang, Zewen Li, Yue Song, Qiuqin Sun, Lu Deng, Lu Deng, Zhiqing Lin, Yang Zeng, Chunhong Qiu, Jingjing Lin, Jingjing Lin, Hui Guo, Jiangfan Chen, Wei Guo   +13 more
doaj   +1 more source

A Dopamine-Acetylcholine Cascade: Simulating Learned and Lesion-Induced Behavior of Striatal Cholinergic Interneurons [PDF]

, 2007
The "teaching signal" that modulates reinforcement learning at cortico-striatal synapses may be a sequence composed of an adaptively scaled DA burst, a brief ACh burst, and a scaled ACh pause.
Bullock, Daniel, Tan, Can Ozan
core   +1 more source

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. [PDF]

, 2016
To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths.
A Dobin, A Hodges, A Kuhn, A Pal, A Reiner, A Valencia, Andreas Tebbe, B Zhang, B Zhang, BM Bolstad, C Zuccato, CA Ross, Christoph Schaab, Daniel J Lavery, David Howland, DI Shirasaki, Doxa Chatzopoulou, DV Zaykin, EH Aylward, Eliana Marisa Ramos, ES Deneris, ES Lein, Fuying Gao, G Fishell, GA Smith, Giovanni Coppola, HT Orr, I Al-Ramahi, IS Seong, Ismael Al-Ramahi, J Cox, J Cox, J Labbadia, JA Miller, JC Jacobsen, JE Phillips, Jeffrey P Cantle, Jeffrey S Aaronson, JF Gusella, JF Gusella, Jim Rosinski, JM Dowen, JM Van Raamsdonk, JP Vonsattel, Juan Botas, K Becanovic, K Monahan, K Sharma, Karla El-Zein, LB Menalled, LB Menalled, LB Menalled, LS Kaltenbach, M Biagioli, M Heiman, M MACDONALD, M Mann, M Mielcarek, MA Pouladi, MC Oldham, MI Love, MK Lobo, MT Lin, N Wang, Nan Wang, P Giles, P Grange, P Langfelder, P Langfelder, P Langfelder, P Langfelder, P Langfelder, Peter Langfelder, PF Durrenberger, RC Gentleman, S Anders, S Horvath, S Toyoda, Sandeep Deverasetty, Seung Kwak, Steve Horvath, T Geiger, T Lu, WE Johnson, WV Chen, X Gu, X Gu, X William Yang, XH Lu, Xiao-Hong Lu, Y Benjamini, Y Guo, Y Shen, Y Wang, Yining Zhao   +94 more
core   +1 more source

Corynebacterium striatum‐Associated Pyogenic Osteomyelitis With Direct Extension From Postoperative Empyema

Respirology Case Reports
Corynebacterium striatum can cause postoperative empyema. C. striatum‐associated empyema may be associated with osteomyelitis. Rifampicin is a viable therapeutic option for C. striatum infection.
Shinnosuke Fukushima, Kazuhiro Noma, Hideharu Hagiya   +2 more
doaj   +1 more source

Chronic corticosterone administration in adolescence enhances dorsolateral striatum-dependent learning in adulthood

Frontiers in Behavioral Neuroscience, 2022
Previous evidence indicates a link between early life stress (ELS) in humans and a predisposition to psychopathologies that are characterized in part by maladaptive habitual behaviors.
Ty M. Gadberry, Jarid Goodman, Mark G. Packard   +2 more
doaj   +1 more source

Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study. [PDF]

, 2016
Adding supraphysiologic doses of levothyroxine (L-T4) to standard treatment for bipolar depression shows promise, but the mechanisms underlying clinical improvement are unknown.
Adli, M, Bauer, M, Berman, S, Hellemann, GS, London, ED, Pilhatsch, M, Plotkin, M, Schlagenhauf, F, Stamm, T, Whybrow, PC   +9 more
core