Bacterial Longevity Requires Protein Synthesis and a Stringent Response [PDF]
mBio, 2019 Gram-negative bacteria in infections, biofilms, and industrial settings often stop growing due to nutrient depletion, immune responses, or environmental stresses.
Liang Yin +5 more
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Phenotypic Heterogeneity in Mycobacterial Stringent Response [PDF]
BMC Systems Biology, 2011 A common survival strategy of microorganisms subjected to stress involves the generation of phenotypic heterogeneity in the isogenic microbial population enabling a subset of the population to survive under stress.
Basu, Joyoti +5 more
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Relacin, a novel antibacterial agent targeting the Stringent Response. [PDF]
PLoS Pathogens, 2012 Finding bacterial cellular targets for developing novel antibiotics has become a major challenge in fighting resistant pathogenic bacteria. We present a novel compound, Relacin, designed to inhibit (p)ppGpp production by the ubiquitous bacterial enzyme ...
Ezequiel Wexselblatt +8 more
doaj +4 more sources
Bio-Protocol, 2016 The stringent response in bacteria is a stress response that is mediated by the signaling molecules guanosine tetraphosphate and pentaphosphate [(p)ppGpp], alarmones that are also directly related to virulence. Therefore, determination of (p)ppGpp levels
Smitha Sivapragasam, Anne Grove
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MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway [PDF]
mLife, 2022 Antibiotic resistance in gram‐negative pathogens has become one of the most serious global public health threats. The role of the N‐acyl homoserine lactone (AHL)‐mediated signaling pathway, which is widespread in gram‐negative bacteria, in the bacterial ...
Qin Dou +14 more
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Bacterial Chromosome Replication and DNA Repair During the Stringent Response [PDF]
Frontiers in Microbiology, 2020 The stringent response regulates bacterial growth rate and is important for cell survival under changing environmental conditions. The effect of the stringent response is pleiotropic, affecting almost all biological processes in the cell including ...
Anurag Kumar Sinha +2 more
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The Stringent Response-Regulated sRNA Transcriptome of Borrelia burgdorferi [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to persist in the tick phase of its enzootic life cycle. We previously found that the stringent response mediated by RelBbu globally regulates gene expression to
Dan Drecktrah +5 more
doaj +3 more sources
The YmgB-SpoT interaction triggers the stringent response in Escherichia coli. [PDF]
J Biol Chem, 2023 Guiraud P +3 more
europepmc +3 more sources
Microbial Primer: what is the stringent response and how does it allow bacteria to survive stress? [PDF]
Microbiology (Reading)Urwin L, Savva O, Corrigan RM.
europepmc +2 more sources
The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly [PDF]
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
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