Results 21 to 30 of about 212,665 (269)
MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway [PDF]
mLife, 2022 Antibiotic resistance in gram‐negative pathogens has become one of the most serious global public health threats. The role of the N‐acyl homoserine lactone (AHL)‐mediated signaling pathway, which is widespread in gram‐negative bacteria, in the bacterial ...
Qin Dou +14 more
doaj +2 more sources
The Stringent Response-Regulated sRNA Transcriptome of Borrelia burgdorferi [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to persist in the tick phase of its enzootic life cycle. We previously found that the stringent response mediated by RelBbu globally regulates gene expression to
Dan Drecktrah +5 more
doaj +3 more sources
The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly [PDF]
Cells, 2019 Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison +2 more
doaj +2 more sources
Role of the Extracytoplasmic Function Sigma Factor SigE in the Stringent Response of <i>Mycobacterium tuberculosis</i>. [PDF]
Microbiol Spectr, 2023 Bacteria respond to nutrient starvation implementing the stringent response, a stress signaling system resulting in metabolic remodeling leading to decreased growth rate and energy requirements.
Baruzzo G +11 more
europepmc +2 more sources
mBio, 2023 Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between concentration of the alarmone (p)ppGpp (ppGpp) and cell ...
Sarah E. Anderson +3 more
doaj +1 more source
(p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in
mBio, 2020 The facultative intracellular pathogen Listeria monocytogenes, like many related Firmicutes, uses the nucleotide second messenger cyclic di-AMP (c-di-AMP) to adapt to changes in nutrient availability, osmotic stress, and the presence of cell wall-acting ...
Bret N. Peterson +8 more
doaj +1 more source
Tolerance and Persistence to Drugs: A Main Challenge in the Fight Against Mycobacterium tuberculosis
Frontiers in Microbiology, 2020 The treatment of tuberculosis is extremely long. One of the reasons why Mycobacterium tuberculosis elimination from the organism takes so long is that in particular environmental conditions it can become tolerant to drugs and/or develop persisters able ...
Francesca Boldrin +4 more
doaj +1 more source
Clinical rel mutations in Staphylococcus aureus prime pathogen expansion under nutrient stress
mSphere, 2023 Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein.
Edwin Chen +6 more
doaj +1 more source
Classic Spotlight: Studies of the Stringent Response [PDF]
Journal of Bacteriology, 2016 The views expressed in this Editorial do not necessarily reflect the views of the journal or of ASM. Early investigators of bacterial metabolism felt that the major activities of the cell must be balanced so that every component of the cell could be duplicated in the same time interval.
Richard L. Gourse, Sean Crosson
openaire +2 more sources
Microbiology Spectrum, 2023 In natural environments, nutrients are usually scarce, causing microorganisms to grow slowly while staying metabolically active. These natural conditions can be simulated using retentostat cultivations.
Angela Rocio Ortiz Camargo +6 more
doaj +1 more source