Bacterial lifestyle shapes stringent response activation [PDF]
Trends in Microbiology, 2013 Bacteria inhabit enormously diverse niches and have a correspondingly large array of regulatory mechanisms to adapt to often inhospitable and variable environments. The stringent response (SR) allows bacteria to quickly reprogram transcription in response to changes in nutrient availability. Although the proteins controlling this response are conserved
Cara C Boutté, Sean Crosson
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Relacin, a novel antibacterial agent targeting the Stringent Response. [PDF]
PLoS Pathogens, 2012 Finding bacterial cellular targets for developing novel antibiotics has become a major challenge in fighting resistant pathogenic bacteria. We present a novel compound, Relacin, designed to inhibit (p)ppGpp production by the ubiquitous bacterial enzyme ...
Ezequiel Wexselblatt +8 more
doaj +4 more sources
Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response
Toxins, 2015 Toxin/antitoxin (TA) systems are nearly universal in prokaryotes; toxins are paired with antitoxins which inactivate them until the toxins are utilized. Here we explore whether toxins may function alone; i.e., whether a toxin which lacks a corresponding ...
Sabina Islam +2 more
doaj +3 more sources
The Stringent Response-Regulated sRNA Transcriptome of Borrelia burgdorferi [PDF]
Frontiers in Cellular and Infection Microbiology, 2018 The Lyme disease spirochete Borrelia (Borreliella) burgdorferi must tolerate nutrient stress to persist in the tick phase of its enzootic life cycle. We previously found that the stringent response mediated by RelBbu globally regulates gene expression to
Dan Drecktrah +5 more
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Targeting the Mycobacterium tuberculosis Stringent Response as a Strategy for Shortening Tuberculosis Treatment [PDF]
Frontiers in Microbiology, 2021 The stringent response is well conserved across bacterial species and is a key pathway involved both in bacterial survival and virulence and in the induction of antibiotic tolerance in Mycobacteria.
Carina Danchik +2 more
doaj +2 more sources
MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway [PDF]
mLife, 2022 Antibiotic resistance in gram‐negative pathogens has become one of the most serious global public health threats. The role of the N‐acyl homoserine lactone (AHL)‐mediated signaling pathway, which is widespread in gram‐negative bacteria, in the bacterial ...
Qin Dou +14 more
doaj +2 more sources
Bacterial Chromosome Replication and DNA Repair During the Stringent Response [PDF]
Frontiers in Microbiology, 2020 The stringent response regulates bacterial growth rate and is important for cell survival under changing environmental conditions. The effect of the stringent response is pleiotropic, affecting almost all biological processes in the cell including ...
Anurag Kumar Sinha +2 more
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A role for the stringent response in ciprofloxacin resistance in Pseudomonas aeruginosa. [PDF]
Sci RepAbstractPseudomonas aeruginosa is a major cause of nosocomial infections and the leading cause of chronic lung infections in cystic fibrosis and chronic obstructive pulmonary disease patients. Antibiotic treatment remains challenging because P. aeruginosa is resistant to high concentrations of antibiotics and has a remarkable ability to acquire ...
García-Villada L +4 more
europepmc +4 more sources
Inorganic polyphosphate and the stringent response coordinately control cell division and cell morphology in Escherichia coli [PDF]
mBioBacteria encounter numerous stressors in their constantly changing environments and have evolved many methods to deal with stressors quickly and effectively.
Christopher W. Hamm, Michael J. Gray
doaj +2 more sources
mBio, 2023 Bacterial cell size is a multifactorial trait that is influenced by variables including nutritional availability and the timing of cell division. Prior work revealed a negative correlation between concentration of the alarmone (p)ppGpp (ppGpp) and cell ...
Sarah E. Anderson +3 more
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