Results 41 to 50 of about 212,665 (269)

Role of RelA and SpoT in Burkholderia pseudomallei Virulence and Immunity [PDF]

, 2012
Burkholderia pseudomallei is a Gram-negative soil bacterium and the causative agent of melioidosis, a disease of humans and animals. It is also listed as a category B bioterrorism threat agent by the U.S.
Wand, ME, Müller, CM, Conejero, L, Bancroft, Gregory J, Spink, N, Titball, Richard W., Titball, Richard W, Wand, Matthew E, Bancroft, Gregory J., Müller, Claudia M, Conejero, Laura, Spink, Natasha   +11 more
core   +1 more source

Characterization of the stringent and relaxed responses of Streptococcus equisimilis [PDF]

Journal of Bacteriology, 1997
The 739-codon rel(Seq) gene of Streptococcus equisimilis H46A is bifunctional, encoding a strong guanosine 3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGppase) and a weaker ribosome-independent ATP:GTP 3'-pyrophosphoryltransferase [(p)ppGpp synthetase]. To analyze the function of this gene, (p)ppGpp accumulation patterns as well as protein and RNA
U, Mechold, H, Malke
openaire   +2 more sources

The C-Terminal RRM/ACT Domain Is Crucial for Fine-Tuning the Activation of ‘Long’ RelA-SpoT Homolog Enzymes by Ribosomal Complexes

Frontiers in Microbiology, 2020
The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be ...
Hiraku Takada, Hiraku Takada, Mohammad Roghanian, Mohammad Roghanian, Victoriia Murina, Victoriia Murina, Ievgen Dzhygyr, Ievgen Dzhygyr, Rikinori Murayama, Genki Akanuma, Gemma C. Atkinson, Abel Garcia-Pino, Abel Garcia-Pino, Vasili Hauryliuk, Vasili Hauryliuk, Vasili Hauryliuk   +15 more
doaj   +1 more source

Pleiotropic effects of PipX, PipY, or RelQ overexpression on growth, cell size, photosynthesis, and polyphosphate accumulation in the cyanobacterium Synechococcus elongatus PCC7942

Frontiers in Microbiology, 2023
The cyanobacterial protein PipY belongs to the Pyridoxal-phosphate (PLP)-binding proteins (PLPBP/COG0325) family of pyridoxal-phosphate-binding proteins, which are represented in all three domains of life.
Antonio Llop, Antonio Llop, Jose I. Labella, Marina Borisova, Karl Forchhammer, Khaled A. Selim, Asunción Contreras   +6 more
doaj   +1 more source

(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism

Frontiers in Microbiology, 2020
When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen, Victor Zegarra, Gert Bange   +2 more
doaj   +1 more source

Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase

, 2006
Brockmann-Gretza O, Kalinowski J. Global gene expression during stringent response in Corynebacterium glutamicum in presence and absence of the rel gene encoding (p) ppGpp synthase. BMC Genomics.
Brockmann-Gretza Olaf, Kalinowski Jörn, Kalinowski, Jörn, Brockmann-Gretza, Olaf, Olaf Brockmann-Gretza, Jörn Kalinowski   +5 more
core   +1 more source

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

Nitrofurantoin Prompts the Stringent Response in Bacillus subtilis [PDF]

Microbiology, 1981
Nitrofurantoin causes the stringent response in Bacillus subtilis. After exposure of a stringent strain to this drug, the intracellular concentrations of guanosine 3'-diphosphate 5'-diphosphate (ppGpp), guanosine 3'-diphosphate 5'-triphosphate (pppGpp) and ATP increased, while that of GTP decreased.
J M, Lopez, P, Fortnagel
openaire   +2 more sources

(p)ppGpp and CodY Promote Enterococcus faecalis Virulence in a Murine Model of Catheter-Associated Urinary Tract Infection

mSphere, 2019
In Firmicutes, the nutrient-sensing regulators (p)ppGpp, the effector molecule of the stringent response, and CodY work in tandem to maintain bacterial fitness during infection. Here, we tested (p)ppGpp and codY mutant strains of Enterococcus faecalis in
C. Colomer-Winter, A. L. Flores-Mireles, S. Kundra, S. J. Hultgren, J. A. Lemos   +4 more
doaj   +1 more source

Stringent response.

, 2014
(A) During the stringent response RNA polymerases involved in rRNA transcription are quickly released to increase the pool of free cores. (B) Number of holoenzymes and as a function of the copy number of core RNAPs.
Marco Mauri (642015), Stefan Klumpp (123336)   +1 more
core   +1 more source