Results 41 to 50 of about 207,701 (143)
mSystems, 2021 Chlamydia trachomatis and Streptococcus pyogenes are among the most prevalent bacterial pathogens of humans. Interestingly, both pathogens are tryptophan (Trp) auxotrophs and must acquire this essential amino acid from their environment.
Scot P. Ouellette +4 more
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Frontiers in Microbiology, 2019 The alarmone species ppGpp and pppGpp are elementary components of bacterial physiology as they both coordinate the bacterial stress response and serve as fine-tuners of general metabolism during conditions of balanced growth.
Matthias Ruwe +4 more
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The stringent response and Mycobacterium tuberculosis pathogenesis [PDF]
Pathogens and Disease, 2018 Abstract During infection, the host restrains Mycobacterium tuberculosis (Mtb) from proliferating by imposing an arsenal of stresses. Despite this onslaught of attacks, Mtb is able to persist for the lifetime of the host, indicating that this pathogen has substantial molecular mechanisms to resist host-inflicted damage.
Jerome, Prusa +2 more
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Characterization of the stringent and relaxed responses of Streptococcus equisimilis [PDF]
Journal of Bacteriology, 1997 The 739-codon rel(Seq) gene of Streptococcus equisimilis H46A is bifunctional, encoding a strong guanosine 3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGppase) and a weaker ribosome-independent ATP:GTP 3'-pyrophosphoryltransferase [(p)ppGpp synthetase]. To analyze the function of this gene, (p)ppGpp accumulation patterns as well as protein and RNA
U, Mechold, H, Malke
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Frontiers in Microbiology, 2020 The (p)ppGpp-mediated stringent response is a bacterial stress response implicated in virulence and antibiotic tolerance. Both synthesis and degradation of the (p)ppGpp alarmone nucleotide are mediated by RelA-SpoT Homolog (RSH) enzymes which can be ...
Hiraku Takada +15 more
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Frontiers in Microbiology, 2023 The cyanobacterial protein PipY belongs to the Pyridoxal-phosphate (PLP)-binding proteins (PLPBP/COG0325) family of pyridoxal-phosphate-binding proteins, which are represented in all three domains of life.
Antonio Llop +6 more
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Frontiers in Plant Science, 2022 A RelA/SpoT homolog, HpRSH, was identified in Haematococcus pluvialis. HpRSH was found to catalyze Mg2+-dependent guanosine tetraphosphate (ppGpp) synthesis and Mn2+-dependent ppGpp hydrolysis, respectively.
Hui Jin +4 more
doaj +1 more source
Nitrofurantoin Prompts the Stringent Response in Bacillus subtilis [PDF]
Microbiology, 1981 Nitrofurantoin causes the stringent response in Bacillus subtilis. After exposure of a stringent strain to this drug, the intracellular concentrations of guanosine 3'-diphosphate 5'-diphosphate (ppGpp), guanosine 3'-diphosphate 5'-triphosphate (pppGpp) and ATP increased, while that of GTP decreased.
J M, Lopez, P, Fortnagel
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The stringent response in Streptomyces coelicolor A3(2) [PDF]
Molecular Microbiology, 1991 SummaryThe stringent response was elicited in the antibiotic producer Streptomyces coelicolor A3(2) either by amino acid depletion (nutritional shiftdown) or by the addition of serine hydroxamate; both led to increased levels of ppGpp and to a reduction in transcription from the four promoters of the rrnD rRNA gene set.
Strauch, E. +3 more
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(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism
Frontiers in Microbiology, 2020 When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen +2 more
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