Results 61 to 70 of about 207,701 (143)
Ribosome•RelA structures reveal the mechanism of stringent response activation
eLife, 2016 Stringent response is a conserved bacterial stress response underlying virulence and antibiotic resistance. RelA/SpoT-homolog proteins synthesize transcriptional modulators (p)ppGpp, allowing bacteria to adapt to stress.
Anna B Loveland +6 more
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Helicobacter pylori : a Eubacterium Lacking the Stringent Response [PDF]
Journal of Bacteriology, 1999 ABSTRACT Accumulation of 16S rRNA and production of guanosine polyphosphates (pppGpp and ppGpp) were studied during amino acid starvation in three wild-type strains of Helicobacter pylori . All strains exhibit a relaxed phenotype with respect to accumulation of 16S rRNA.
G L, Scoarughi, C, Cimmino, P, Donini
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Crucial Role of ppGpp in the Resilience of
mSphere, 2020 Bacteria grow in constantly changing environments that can suddenly become completely depleted of essential nutrients. The stringent response, a rewiring of the cellular metabolism mediated by the alarmone (p)ppGpp, plays a crucial role in adjusting ...
Clément Patacq +2 more
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The stringent response promotes biofilm dispersal in Pseudomonas putida [PDF]
Scientific Reports, 2017 AbstractBiofilm dispersal is a genetically programmed response enabling bacterial cells to exit the biofilm in response to particular physiological or environmental conditions. InPseudomonas putidabiofilms, nutrient starvation triggers c-di-GMP hydrolysis by phosphodiesterase BifA, releasing inhibition of protease LapG by the c-di-GMP effector protein ...
Carlos Díaz-Salazar +8 more
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Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA
Frontiers in Microbiology, 2019 Amino acid starvation in Escherichia coli activates the enzymatic activity of the stringent factor RelA, leading to accumulation of the alarmone nucleotide (p)ppGpp.
Kathryn Jane Turnbull +11 more
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Frontiers in Microbiology, 2020 Stringent response mediated by modified guanosine nucleotides is conserved across bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT proteins synthesize the modified nucleotides ppGpp and pppGpp, together referred
Rajeshree Sanyal +2 more
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Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus [PDF]
Journal of General Microbiology, 1991 Cephalosporin biosynthetic activity and extracellular protease production increased during growth of Streptomyces clavuligerus in defined medium, while the level of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) remained very low and stable. Cephalosporin biosynthesis (measured in resting cell systems) was initiated during early exponential growth in ...
V, Bascarán +3 more
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Emerging Microbes and InfectionsYersinia pestis, the etiological agent of the devastating plague, has caused three pandemics in human history. While known for its fatality, it has long been intriguing that biovar microtus strains are highly attenuated to humans.
Hongyan Chen +11 more
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The Stringent Response in Phototrophs
, 2012 Organisms must respond to environmental changes if they are to survive. As a result, species have evolved numerous intracellular and intercellular regulatory systems that often reflect an organism’s environment. In bacteria, one of the most important regulatory systems is the stringent response (Cashel et al., 1996).
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mBio, 2019 The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer +2 more
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