Results 11 to 20 of about 212,665 (269)

The stringent response and cell cycle arrest in Escherichia coli. [PDF]

PLoS Genetics, 2008
The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp. We characterize the replication arrest that occurs during the stringent response in Escherichia coli.
Daniel J Ferullo, Susan T Lovett
doaj   +5 more sources

Bacterial Longevity Requires Protein Synthesis and a Stringent Response [PDF]

mBio, 2019
Gram-negative bacteria in infections, biofilms, and industrial settings often stop growing due to nutrient depletion, immune responses, or environmental stresses.
Liang Yin, Hongyu Ma, Ernesto S. Nakayasu, Samuel H. Payne, David R. Morris, Caroline S. Harwood   +5 more
doaj   +4 more sources

Phenotypic heterogeneity in mycobacterial stringent response [PDF]

BMC Systems Biology, 2011
Background A common survival strategy of microorganisms subjected to stress involves the generation of phenotypic heterogeneity in the isogenic microbial population enabling a subset of the population to survive under stress.
Joyoti Basu, Ghosh, Sayantari, Sayantari Ghosh, Indrani Bose, Manikuntala Kundu, Ghosh, Bhaswar, Bhaswar Ghosh, Sureka, Kamakshi, Bose, Indrani, Basu, Joyoti, Kundu, Manikuntala, Kamakshi Sureka   +11 more
core   +4 more sources

Microbial Primer: what is the stringent response and how does it allow bacteria to survive stress? [PDF]

Microbiology (Reading)
The stringent response is a conserved bacterial stress response that allows bacteria to alter their activity and survive under nutrient-limiting conditions.
Urwin L, Savva O, Corrigan RM.
europepmc   +4 more sources

Relacin, a novel antibacterial agent targeting the Stringent Response. [PDF]

PLoS Pathogens, 2012
Finding bacterial cellular targets for developing novel antibiotics has become a major challenge in fighting resistant pathogenic bacteria. We present a novel compound, Relacin, designed to inhibit (p)ppGpp production by the ubiquitous bacterial enzyme ...
Ezequiel Wexselblatt, Yaara Oppenheimer-Shaanan, Ilana Kaspy, Nir London, Ora Schueler-Furman, Eylon Yavin, Gad Glaser, Joshua Katzhendler, Sigal Ben-Yehuda   +8 more
doaj   +4 more sources

Revisiting the stringent response, ppGpp and starvation signaling

Current Opinion in Microbiology, 2001
Microbial adaptation to environmental stress plays an important role in survival. It is necessary to understand the mechanisms underlying the survival of microbes under stress, as they may eventually aid in the successful control of the growth and ...
Anil Kumar Ojha, Ojha, Anil Kumar, Dipankar Chatterji, Chatterji, Dipankar   +3 more
core   +4 more sources

ppGpp: Stringent response and survival

Journal of microbiology (Seoul, Korea), 2006
Adaptation to any undesirable change in the environment dictates the survivability of many microorganisms, with such changes generating a quick and suitable response, which guides the physiology of bacteria.
Jain, Vikas, Kumar, Manish, Chatterji, Dipankar   +2 more
core   +4 more sources

The stringent response in Streptomyces coelicolor A3(2) [PDF]

Molecular Microbiology, 1991
The stringent response was elicited in the antibiotic producer Streptomyces coelicolor A3(2) either by amino acid depletion (nutritional shiftdown) or by the addition of serine hydroxamate; both led to increased levels of ppGpp and to a reduction in ...
Takano, E.; id_orcid, H. A. Baylts, Takano, E., Strauch, E.,, Strauch, E., Baylis, H.A., Baylis, H. A., Bibb, M. J., Bibb, M.J., M. J. Bibb, Baylis, H.A.,, E. Takano, Takano, E.,, Bibb, M.J.,, E. Strauch   +14 more
core   +5 more sources

An intranasal stringent response vaccine targeting dendritic cells as a novel adjunctive therapy against tuberculosis [PDF]

Frontiers in Immunology, 2022
Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent Mycobacterium tuberculosis (Mtb) to remain in a non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induction
Styliani Karanika, Styliani Karanika, James T. Gordy, Pranita Neupane, Pranita Neupane, Theodoros Karantanos, Jennie Ruelas Castillo, Jennie Ruelas Castillo, Darla Quijada, Darla Quijada, Kaitlyn Comstock, Avinaash K. Sandhu, Aakanksha R. Kapoor, Aakanksha R. Kapoor, Yinan Hui, Samuel K. Ayeh, Samuel K. Ayeh, Rokeya Tasneen, Rokeya Tasneen, Stefanie Krug, Stefanie Krug, Carina Danchik, Carina Danchik, Tianyin Wang, Courtney Schill, Richard B. Markham, Petros C. Karakousis, Petros C. Karakousis   +27 more
doaj   +2 more sources

The stringent response promotes biofilm dispersal in Pseudomonas putida [PDF]

Scientific Reports, 2017
Biofilm dispersal is a genetically programmed response enabling bacterial cells to exit the biofilm in response to particular physiological or environmental conditions.
Calero, Patricia, María G. Velasco-Domínguez, Victoria Shingler, Patricia Calero, Lisa Wirebrand, Espinosa-Portero, Rocío, Velasco-Domínguez, María G., Díaz-Salazar, Carlos, Carlos Díaz-Salazar, Shingler, Victoria,, Jiménez-Fernández, Alicia, Aroa López-Sánchez, Fernando Govantes, Wirebrand, Lisa, Alicia Jiménez-Fernández, Rocío Espinosa-Portero, Wirebrand, Lisa,, López-Sánchez, Aroa, Shingler, Victoria, Govantes, Fernando   +19 more
core   +5 more sources