Results 71 to 80 of about 665,456 (302)

Rel is required for morphogenesis of resting cells in Mycobacterium smegmatis

open access: yesFrontiers in Microbiology, 2016
Recently we showed that upon transfer of growing Mycobacterium smegmatis into saline, the bacilli exited the canonical cell division cycle and formed septated multi-nucleoided cells. Under shock starvation (i.e.
Mu-Lu Wu, Chuu Ling Chan, Thomas Dick
doaj   +1 more source

Molecular dissection of the mycobacterial stringent response protein Rel [PDF]

open access: yesProtein Science, 2006
AbstractLatency in Mycobacterium tuberculosis poses a barrier in its complete eradication. Overexpression of certain genes is one of the factors that help these bacilli survive inside the host during latency. Among these genes, rel, which leads to the expression of Rel protein, plays an important role by synthesizing the signaling molecule ppGpp using ...
Vikas, Jain   +3 more
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Stringent Response Regulation of Biofilm Formation in Vibrio cholerae [PDF]

open access: yesJournal of Bacteriology, 2012
ABSTRACT Biofilm formation is a key factor in Vibrio cholerae environmental survival and host colonization. Production of biofilm enables V. cholerae to survive and persist in aquatic environments and aids in the passage through the gastric acid barrier to allow access to the small ...
Huajun, He   +3 more
openaire   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Parasitic-free modulation of semiconductor lasers [PDF]

open access: yes, 1989
Active-layer photomixing is a technique for modulating semiconductor lasers with nearly perfect immunity to device parasitics. Measurements of the intrinsic modulation response of a laser diode using this technique at temperatures as low as 4.2 K are ...
Newkirk, Michael A., Vahala, Kerry J.
core  

Combinatorial stress responses: direct coupling of two major stress responses in Escherichia coli

open access: yes, 2014
Nitrogen is an essential element for all life, and this is no different for the bacterial cell. Numerous cellular macromolecules contain nitrogen, including proteins, nucleic acids and cell wall components.
Barton, G   +4 more
core   +3 more sources

The SKA Particle Array Prototype: The First Particle Detector at the Murchison Radio-astronomy Observatory

open access: yes, 2020
We report on the design, deployment, and first results from a scintillation detector deployed at the Murchison Radio-astronomy Observatory (MRO).
Bray, J. D.   +20 more
core   +1 more source

Widening access in selection using situational judgement tests: evidence from the UKCAT [PDF]

open access: yes, 2016
CONTEXT Widening access promotes student diversity and the appropriate representation of all demographic groups. This study aims to examine diversity-related benefits of the use of situational judgement tests (SJTs) in the UK Clinical Aptitude Test ...
Corstjens, Jan   +4 more
core   +2 more sources

Helicobacter pylori : a Eubacterium Lacking the Stringent Response [PDF]

open access: yesJournal of Bacteriology, 1999
ABSTRACT Accumulation of 16S rRNA and production of guanosine polyphosphates (pppGpp and ppGpp) were studied during amino acid starvation in three wild-type strains of Helicobacter pylori . All strains exhibit a relaxed phenotype with respect to accumulation of 16S rRNA.
G L, Scoarughi, C, Cimmino, P, Donini
openaire   +2 more sources

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