Results 41 to 50 of about 5,180,263 (277)

Outcome of Stroke Patients with Cancer and Nonbacterial Thrombotic Endocarditis [PDF]

open access: yes, 2020
Background and purpose: Nonbacterial thrombotic endocarditis (NBTE) is a cause of stroke in cancer. However, clinical characteristics and outcomes in stroke patients with cancer-associated NBTE are not well known.
최진교   +6 more
core   +1 more source

Consensus-based statements for the management of mitochondrial stroke-like episodes [version 1; peer review: 2 approved]

open access: yesWellcome Open Research, 2019
Background: Focal-onset seizures and encephalopathy are prominent features of a stroke-like episode, which is a severe neurological manifestation associated with subtypes of mitochondrial disease.
Yi Shiau Ng   +11 more
doaj   +1 more source

The Royal Blackburn Hospital, Acute Stroke Unit [PDF]

open access: yes
Stroke Unit ...
Ramsden, Victoria, Philip, Sheeba J.
core   +1 more source

The stroke self-efficacy questionnaire: measuring individual confidence in functional performance after stroke [PDF]

open access: yes, 2008
Aims and objectives. The aim was to develop a questionnaire for use by practitioners working in stroke care to measure self-efficacy judgements in specific domains of functioning relevant to individuals following stroke. Background.
Cecily Partridge   +5 more
core   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian   +8 more
wiley   +1 more source

Assessment of additional endpoints for trials in acute stroke - what, when, where, in who?

open access: yes, 2012
Functional outcome in acute stroke trials among others is usually measured on the modified Rankin Scale. However, new onset of depression, cognitive decline, and communication deficits alone or in combination affect more than 25% of patients. This report
TONI, Danilo   +1 more
core   +1 more source

Data_Sheet_1_Migraine aura-like symptoms at onset of stroke and stroke-like symptoms in migraine with aura.pdf [PDF]

open access: yes, 2022
Background and objectivesIn general, suddenly occurring neurological deficits, i.e., negative neurological symptoms, are considered symptoms of focal cerebral ischemia, while positive irritative symptoms with gradual onset are viewed as the ...
Arnold, Marcel   +28 more
core   +2 more sources

Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Primary mitochondrial disease is a group of genetic disorders caused by pathogenic variants in nuclear or mitochondrial DNA, often resulting in progressive neurodegeneration and cognitive decline. Current management is primarily supportive, though recent research offers hope for disease‐modifying treatments in the future.
Oksana Pogoryelova   +9 more
wiley   +1 more source

Epilepsy and MELAS syndrome: literature review and clinical observation

open access: yesЭпилепсия и пароксизмальные состояния, 2023
MELAS syndrome (mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes) belongs to the group of mitochondrial diseases. Most MELAS syndrome cases are associated with the A3243G mutation in the MTTL1 gene.
А. М. Teplysheva   +2 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

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