Results 41 to 50 of about 37,632,150 (282)
The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia
Frontiers in Neuroscience, 2017 Stromal cell-derived factor-1 is a chemoattractant produced by bone marrow stromal cell lines. It is recognized as a critical factor in the immune and central nervous systems (CNSs) as well as exerting a role in cancer.
Xi Cheng +7 more
doaj +1 more source
Chemotaxis of primitive hematopoietic cells in response to stromal cell–derived factor-1 [PDF]
Journal of Clinical Investigation, 2000 Stromal cell-derived factor-1 (SDF-1) provides a potent chemotactic stimulus for CD34(+) hematopoietic cells. We cultured mobilized peripheral blood (PB) and umbilical cord blood (CB) for up to 5 weeks and examined the migratory activity of cobblestone area-forming cells (CAFCs) and long-term culture-initiating cells (LTC-ICs) in a transwell assay.
D Y, Jo, S, Rafii, T, Hamada, M A, Moore
openaire +2 more sources
Platelet-derived stromal cell-derived factor-1 is required for the transformation of circulating monocytes into multipotential cells. [PDF]
PLoS ONE, 2013 BACKGROUND: We previously described a primitive cell population derived from human circulating CD14(+) monocytes, named monocyte-derived multipotential cells (MOMCs), which are capable of differentiating into mesenchymal and endothelial lineages.
Noriyuki Seta +4 more
doaj +1 more source
, 2014 Stro-1 has proved an efficacious marker for enrichment of skeletal stem and progenitor cells although isolated populations remain heterogeneous, exhibiting variable colony-forming efficiency and osteogenic differentiation potential. The emerging findings
Greenhough, Joanna +7 more
core +1 more source
Role of SDF-1/CXCR4 in cancer-associated fibroblasts [PDF]
Jichu yixue yu linchuang, 2020 Cancer-associated fibroblasts (CAFs), important component of tumor microenvironment, secrete a variety of factors that play an important role in the occurrence and development of malignant tumors. Stromal cell derived factor-1(SDF-1) secreted by CAFs and
YU Biao, LIU Qing, WU Xiao-ming
doaj
Stromal cell-derived factor: pathological and clinical potentialities [PDF]
РМЖ. Мать и дитя, 2020 O.V. Prokhorova1, A.A. Olina2, G.Kh. Tolibova2, T.G. Tral’2 1Ural State Medical University, Yekaterinburg, Russian Federation 2D.O. Ott Research Institute of Obstetrics, Gynecology & Reproduction, St.
O.V. Prokhorova +3 more
doaj
Stromal Cell–Derived Factor 1 as a Biomarker of Heart Failure and Mortality Risk [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2014 Objective— CXCL12 encodes stromal cell–derived factor 1α (SDF-1), which binds to the receptor encoded by CXCR4 . Variation at the CXCL12 locus is associated with coronary artery disease and endothelial progenitor cell numbers, whereas variation
Subha, Subramanian +10 more
openaire +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis [PDF]
, 2012 Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig +3 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source