Results 41 to 50 of about 604,769 (337)
Canine Corneal Stromal Cells Have Multipotent Mesenchymal Stromal Cell Properties In Vitro [PDF]
Stem Cells and Development, 2020 The objective of this study was to determine whether corneal stromal cells (CSCs) from the limbal and central corneal stroma in dogs have multipotent mesenchymal stem/stromal cell (MSC) properties, and whether this cell population can be differentiated into keratocyte-like cells (KDCs). Normal, donated, mesocephalic dog corneas were used to isolate CSC
Kafarnik, C +4 more
openaire +3 more sources
Regulation of pancreatic cancer aggressiveness by stromal stiffening [PDF]
, 2016 No abstract ...
A Neesse +13 more
core +1 more source
Cell Reports, 2017 Summary: Lymph nodes (LNs) are constructed of intricate networks of endothelial and mesenchymal stromal cells. How these lymphoid stromal cells (LSCs) regulate lymphoid tissue remodeling and contribute to immune responses remains poorly understood.
Julia L. Gregory +12 more
doaj +1 more source
Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction. [PDF]
PLoS ONE, 2015 Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those factors are not fully understood. Here, we have identified critical stromal factors that modulate cancer growth positively and negatively.
Manabu Kawada +12 more
doaj +1 more source
Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival [PDF]
, 2015 Leukemic cells from Chronic Lymphocytic Leukemia (CLL) patients interact with stromal cells of the surrounding microenvironment. Mesenchymal Stromal Cells (MSCs) represent the main population in CLL marrow stroma, which may play a key role for disease ...
Ave, Elisa +15 more
core +2 more sources
Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window [PDF]
, 2020 During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC).
Brighton, Paul (Paul J.) +12 more
core +1 more source
Haematologica, 2009 Background Mesenchymal stromal cells are employed in various different clinical settings in order to modulate immune response. However, relatively little is known about the mechanisms responsible for their immunomodulatory effects, which could be ...
Maria Antonietta Avanzini +13 more
doaj +1 more source
Phagocytosis by stroma confounds coculture studies
iScience, 2021 Summary: Signals provided by the microenvironment can modify and circumvent pathway activities that are therapeutically targeted by drugs. Bone marrow stromal cell coculture models are frequently used to study the influence of the bone marrow niche on ex
Sophie A. Herbst +9 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2023 Increased ovarian fibrosis and an expanded stromal cell compartment are the main characteristics of aging ovaries. However, the molecular mechanisms and the key factor of stromal cells underlying ovarian aging remain unclear.
Ye Wei +9 more
doaj +1 more source