Results 41 to 50 of about 333,204 (219)

Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells

Frontiers in Immunology, 2019
The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis.
Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Yosuke Kurashima, Daisuke Tokuhara, Daisuke Tokuhara, Mariko Kamioka, Mariko Kamioka, Mariko Kamioka, Mariko Kamioka, Yutaka Inagaki, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono, Hiroshi Kiyono   +16 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation

eLife, 2014
Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8+ T cells and MHC-II-dependent anergy of CD4+ T cells.
Antonio P Baptista, Ramon Roozendaal, Rogier M Reijmers, Jasper J Koning, Wendy W Unger, Mascha Greuter, Eelco D Keuning, Rosalie Molenaar, Gera Goverse, Marlous M S Sneeboer, Joke M M den Haan, Marianne Boes, Reina E Mebius   +12 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

Journal for ImmunoTherapy of Cancer
Background The immunosuppressive tumor microenvironment reduces immune response effectiveness in stromal-rich tumors, including consensus molecular subtype 4 colorectal cancer (CRC).
Seán O Hynes, Laurence J Egan, Philip D Dunne, Oliver Treacy, Hannah Egan, Thomas Ritter, Margaret Sheehan, Aideen E Ryan, Linda Howard, Li Peng, Michael O’Dwyer, Lizhi Cao, Jenny Che, Shania M Corry, Niamh A Leonard, Aoife Canney, Eileen Reidy, Aoise O’Neill, Kevin Culligan, Norashikin Zakaria, Courtney Bull, Clodagh O’Meara, Anastasija Walsh, Aisling M Hogan   +23 more
doaj   +1 more source

Mesenchymal stromal cells transiently alter the inflammatory milieu post-transplant to delay graft-versus-host disease

Haematologica, 2010
Background Multipotent mesenchymal stromal cells suppress T-cell function in vitro, a property that has underpinned their use in treating clinical steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation ...
Melinda E. Christensen, Brie E. Turner, Laura J. Sinfield, Katarina Kollar, Hannah Cullup, Nigel J. Waterhouse, Derek N.J. Hart, Kerry Atkinson, Alison M. Rice   +8 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cathepsin D Expression in Colorectal Adenocarcinomas and Adenomas

The International Journal of Biological Markers, 2002
The aim of this study was to investigate the role of cathepsin D in colorectal cancer. For this purpose cathepsin D expression was evaluated by means of immunohistochemistry in stromal and tumor cells of 31 colorectal carcinomas and 29 adenomas ...
Y. Kanber, N.R. Demirbag, A.D. Sam, N. Aydin   +3 more
doaj   +1 more source

Corneal stromal stem cells restore transparency after N2 injury in mice

Stem Cells Translational Medicine, 2020
Corneal scarring associated with various corneal conditions is a leading cause of blindness worldwide. The present study aimed to test the hypothesis that corneal stromal stem cells have a therapeutic effect and are able to restore the extracellular ...
Djida Ghoubay, Marie Borderie, Kate Grieve, Raphaël Martos, Romain Bocheux, Thu‐Mai Nguyen, Patrice Callard, Alain Chédotal, Vincent M. Borderie   +8 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source