Results 71 to 80 of about 864,768 (299)

Molecular dynamic simulations reveal suboptimal binding of salbutamol in T164I variant of β2 adrenergic receptor. [PDF]

PLoS ONE, 2017
The natural variant C491T (rs1800088) in ADRB2 gene substitutes Threonine to Isoleucine at 164th position in β2AR and results in receptor sequestration and altered binding of agonists.
Srinivas Bandaru, Mallika Alvala, Anuraj Nayarisseri, Saphy Sharda, Himshikha Goud, Hema Prasad Mundluru, Sanjeev Kumar Singh   +6 more
doaj   +1 more source

Chance Constrained Mixed Integer Program: Bilinear and Linear Formulations, and Benders Decomposition [PDF]

, 2014
In this paper, we study chance constrained mixed integer program with consideration of recourse decisions and their incurred cost, developed on a finite discrete scenario set.
An, Yu, Kuznia, Ludwig, Zeng, Bo
core  

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Phase behavior of two-component lipid membranes: theory and experiments

, 2012
The structure of the ripple phase of phospholipid membranes remains poorly understood in spite of a large number of theoretical studies, with many experimentally established structural features of this phase unaccounted for.
Kamal, Md. Arif, Pal, Antara, Raghunathan, V. A., Rao, Madan   +3 more
core   +1 more source

Analysis of a selected node of a truss made of cold-rolled sections based on the finite element method [PDF]

, 2018
The study presents a comparative analysis of displacements and reduced stresses that occur in the selected node of a truss made of cold-rolled sections. Computations were based on the finite element method using the Autodesk ROBOT Structural Analysis
Kalinowski, Jaroslaw, Kosin, Mariusz, Major, Izabela, Major, Maciej   +3 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Toward understanding the role of genomic repeat elements in neurodegenerative diseases

Neural Regeneration Research
Neurodegenerative diseases cause great medical and economic burdens for both patients and society; however, the complex molecular mechanisms thereof are not yet well understood.
Zhengyu An, Aidi Jiang, Jingqi Chen
doaj   +1 more source

Structural Analysis of the SARS-CoV-2 Omicron Variant Proteins

Research, 2021
The spread of the latest SARS-CoV-2 variant Omicron is particularly concerning because of the large number of mutations present in its genome and lack of knowledge about how these mutations would affect the current SARS-CoV-2 vaccines and treatments ...
Qiangzhen Yang, Ali Alamdar Shah Syed, Aamir Fahira, Yongyong Shi   +3 more
doaj   +1 more source

A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1

Computational and Structural Biotechnology Journal, 2023
This study investigates the functional significance of assorted variants of uncertain significance (VUS) in euchromatic histone lysine methyltransferase 1 (EHMT1), which is critical for early development and normal physiology.
Young-In Chi, Salomão D. Jorge, Davin R. Jensen, Brian C. Smith, Brian F. Volkman, Angela J. Mathison, Gwen Lomberk, Michael T. Zimmermann, Raul Urrutia   +8 more
doaj   +1 more source