Results 81 to 90 of about 4,111,769 (301)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Optimising building structural topologies

, 2014
A strategy to perform structural optimisation at early stages of the building design process has been developed. It uses a complete building spatial design as input to generate astructural topology.
Papadrakakis, M., Davila Delgado, J.M., Lagaros, N.D., Karlaftis, M.G., Hofmeyer, H.   +4 more
core  

Structural and functional studies on Nod Like Receptors: insights into NAIP/NLRC4 inflammasome formation [PDF]

, 2013
Our immune system is under constant attack of invading pathogens. The initiation of an appropriate immune response that leads to clearance of these microorganisms and infected cells is dependent on the ability of the immune system to discern between ...
Sub Crystal and Structural Chemistry, Crystal and Structural Chemistry, Halff, E.F.   +2 more
core  

A complex structural variant at the KIT locus in cattle with the Pinzgauer spotting pattern. [PDF]

, 2019
A specific white spotting phenotype, termed finching or line-backed spotting, is known for all Pinzgauer cattle and occurs occasionally in Tux-Zillertaler cattle, two Austrian breeds.
Mészáros, G., Leeb, T., A. Letko, Küttel, Luzia Marlis, I. M. Häfliger, T. Leeb, Küttel, L., Hirsbrunner, G., S. Joller, Häfliger, Irene Monika, Hirsbrunner, Gabriela, Joller, Sara, Sölkner, J, Letko, Anna, Drögemüller, C., J. Sölkner, Flury, C, Letko, A., G. Mészáros, Sölkner, J., Flury, Christine, L. Küttel, C. Drögemüller, Häfliger, I. M., G. Hirsbrunner, C. Flury, Leeb, Tosso, Signer-Hasler, Heidi, Mészáros, G, H. Signer‐Hasler, Joller, S.   +30 more
core   +2 more sources

Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4 [PDF]

, 2020
Ticks, as blood-sucking parasites, have developed a complex strategy to evade and suppress host immune responses during feeding. The crucial part of this strategy is expression of a broad family of salivary proteins, called Evasins, to neutralize ...
Heinzmann, Alexandra C A, Koenen, Rory R, Crystal and Structural Chemistry, Koenen, Rory R.; id_orcid, Hackeng, Tilman M.; id_orcid, Denisov, Stepan S., Ippel, Johannes H., Dijkgraaf, Ingrid, Dawson, Philip E., Hackeng, Tilman M., Janssen, Bert J C, Ramirez-Escudero, Mercedes, Ippel, Johannes H, Sub Crystal and Structural Chemistry, Janssen, Bert J. C., Denisov, Stepan S, Dawson, Philip E, Dijkgraaf, Ingrid; id_orcid, Hackeng, Tilman M, Heinzmann, Alexandra C. A., Koenen, Rory R.   +20 more
core   +2 more sources

GeVaCT - Genomic Variant Classifier Tool

, 2016
High throughput screening (HTS) techniques, like mendeliome, whole exomeand genome screening, are becoming a routine in a clinical diagnosticsetting. However, classifying the identified genomic variants as benign or(likely) pathogenic, is still a tedious
Farid, D., Bonduelle, M.L., Nowé, A., Van Dooren, S., Croes, D., Sengupta, D., Daneels, D., Grau, I.   +7 more
core   +3 more sources

Loqusdb: added value of an observations database of local genomic variation

BMC Bioinformatics, 2020
Background Exome and genome sequencing is becoming the method of choice for rare disease diagnostics. One of the key challenges remaining is distinguishing the disease causing variants from the benign background variation.
Måns Magnusson, Jesper Eisfeldt, Daniel Nilsson, Adam Rosenbaum, Valtteri Wirta, Anna Lindstrand, Anna Wedell, Henrik Stranneheim   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

A Variant Branching Pattern of the Aortic Arch: A Case Report. [PDF]

, 2011
Variant aortic arch branching pattern may occur with different embryological mechanisms. We report on a variant aortic arch branching in a 41-year old Tanzanian male cadaver during dissection practice.
Rambau, Peter, Japhet Gilyoma, Mange Manyama, Peter Rambau, Manyama, Mange, Rambau Peter, Manyama Mange, Gilyoma Japhet, Mahalu William, Mahalu, William, Gilyoma, Japhet, William Mahalu   +11 more
core   +2 more sources