Results 91 to 100 of about 2,448,479 (335)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Global Schumpeterian Dynamics with Structural Variations

Bulletin of the South Ural State University. Series "Mathematical Modelling, Programming and Computer Software", 2019
Summary: In this paper, we present the investigations developing the schumpeterian theory of endogenous evolution of economic systems. The proposed approach allows to simulate the emergence and propagation of new technologies. We develop a mathematical model of dynamics of sector capital distribution over efficiency levels on the base of the system of ...
Kirillov, A.N., Sazonov, A.M.
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Erratum: Patient-specific assays based on whole-genome sequencing data to measure residual disease in children with acute lymphoblastic leukemia: A proof of concept study

Frontiers in Oncology, 2023
Frontiers Production Office
doaj   +1 more source

Long-read sequencing reveals novel structural variation markers for key agronomic and quality traits of food-grade soybean

Frontiers in Plant Science
Long read sequencing has been widely used to detect structure variations that are not captured by short read sequencing in plant genomic research.
Zhibo Wang, Kassaye Belay, Kassaye Belay, Joe Paterson, Patrick Bewick, William Singer, Qijian Song, Bo Zhang, Song Li   +8 more
doaj   +1 more source

Variations in urban population structure [PDF]

Demography, 1964
Hasta ahara no se ha prestado atencion suficiente, en materia de investigacion, al estudio sistematico y cuantitativo de la persisiencia y las variaciones en el tiempo de las caracteristicas espaciales de la distribucion y composicion de la poblacion. Utilizando datos de distritos censales para 1940 y 1960 en dos ciudades (Seatle y Rochester), el autor
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Whole-Genome Resequencing and Pan-Transcriptome Reconstruction Highlight the Impact of Genomic Structural Variation on Secondary Metabolite Gene Clusters in the Grapevine Esca Pathogen Phaeoacremonium minimum

Frontiers in Microbiology, 2018
The Ascomycete fungus Phaeoacremonium minimum is one of the primary causal agents of Esca, a widespread and damaging grapevine trunk disease. Variation in virulence among Pm.
Mélanie Massonnet, Abraham Morales-Cruz, Andrea Minio, Rosa Figueroa-Balderas, Daniel P. Lawrence, Renaud Travadon, Philippe E. Rolshausen, Kendra Baumgartner, Dario Cantu   +8 more
doaj   +1 more source

Additional file 10 of Characterization of structural variation in Tibetans reveals new evidence of high-altitude adaptation and introgression

, 2021
Cheng Quan, Yuanfeng Li, Xinyi Liu, Yahui Wang, Jie Ping, Yiming Lu, Gangqiao Zhou   +6 more
openalex   +1 more source

Variations in Structural MRI Quality Significantly Impact Commonly-Used Measures of Brain Anatomy [PDF]

, 2020
Alysha D. Gilmore, Nicholas J. Buser, Jamie L. Hanson   +2 more
openalex   +1 more source