Results 121 to 130 of about 691,412 (269)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The landscape of structural variation in pediatric cancer. [PDF]

Cancer Cell
Greenhalgh R, Brady SW, Yang W, Flasch DA, Edmonson MN, Terekhanova NV, Liu Y, Wang J, Szlachta KA, Tian L, Putnam DK, Rahbarinia D, Kolekar P, Zhou X, Gerhard DS, Ma X, Zhang J.   +16 more
europepmc   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

The biomedical landscape of genomic structural variation in the qatari population. [PDF]

Nat Commun
Aliyev E, Syed N, Visconti A, Aliyev T, Belkadi A, Ghorbani M, Rossi N, Naeem H, Gandhi GD, Thareja G, Al-Maraghi A, Aamer W, Ibrahim AA, Shaath R, Al-Ajli FO, Razali RM, Sedlazeck FJ, Davila S, Akil A, Suhre K, Mokrab Y, Falchi M, Fakhro KA.   +22 more
europepmc   +1 more source

Targeted structural variations [PDF]

Nature Methods, 2012
openaire   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

A simple method to efficiently generate structural variation in plants. [PDF]

PLoS Genet
Bechen LL, Ahsan N, Bahrainwala A, Gehring M, Satyaki PRV.   +4 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Genomic structural variation underlies cell type-specific betacyanin variegation in Chenopodium quinoa. [PDF]

Stress Biol
Zhang Z, Wang Y, Hu X, Yu T, Feng Y, Zhang J, Zhang T, Feng G, Zhang H.   +8 more
europepmc   +1 more source