Results 11 to 20 of about 800,936 (315)

Prediction of structural variation [PDF]

Current Opinion in Structural Biology
Proteins are dynamic molecules that transition between conformational states to perform their functions, and characterizing the protein ensemble is important for understanding biology and therapeutic applications. While recent breakthroughs in machine learning have enabled the prediction of high-quality static models of individual proteins, generating ...
Yogesh Kalakoti, Airy Sanjeev, Björn Wallner   +2 more
openaire   +4 more sources

Author Correction: Patterns of somatic structural variation in human cancer genomes (Nature, (2020), 578, 7793, (112-121), 10.1038/s41586-019-1913-9) [PDF]

, 2023
In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these members should have been included in the main paper.
PCAWG Structural Variation Working Group, PCAWG Consortium   +1 more
core   +1 more source

Fully phased human genome assembly without parental data using single-cell strand sequencing and long reads [PDF]

, 2021
Human genomes are typically assembled as consensus sequences that lack information on parental haplotypes. Here we describe a reference-free workflow for diploid de novo genome assembly that combines the chromosome-wide phasing and scaffolding ...
Sorensen, Melanie, Ebler, Jana, Marijon, P., Ebert, Peter, Sanders, A.D., Pierre Marijon, Mitchell R. Vollger, Korbel, J., Marijon, Pierre, Paten, B., Harvey, W.T., Melanie Sorensen, Benedict Paten, Ashley D. Sanders, Marschall, T., Sulovari, A., Haukness, Marina, Lee, Charles, Maryam Ghareghani, Audano, P., Peter A. Audano, Scott E. Devine, Structural Variation Consortium, Human Genome, Ebert, P., Marschall, Tobias, Paten, Benedict, Katherine M. Munson, Ebler, J., Harvey, W., Peter Ebert, Lansdorp, P., David Porubsky, Jan O. Korbel, Chaisson, Mark J P, Haukness, M., William T. Harvey, Eichler, E.E., Arvis Sulovari, Eichler, E., Chaisson, M.J.P., Chaisson, M., Vollger, Mitchell R, Vollger, M.R., Sanders, Ashley D, Evan E. Eichler, Ghareghani, M., Harvey, William T, Tobias Marschall, Jana Ebler, Peter M. Lansdorp, Mark J. P. Chaisson, Devine, Scott E, Lansdorp, P.M., Sanders, A., Audano, P.A., Eichler, Evan E, Porubsky, D., Sulovari, Arvis, Devine, S.E., Devine, S., Ghareghani, Maryam, Porubsky, David, Munson, K.M., Vollger, M., Sorensen, M., Audano, Peter A, Charles Lee, Lansdorp, Peter M, Munson, Katherine M, Munson, K., Korbel, J.O., Marina Haukness, Korbel, Jan O, Lee, C.   +73 more
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Patterns of somatic structural variation in human cancer genomes [PDF]

, 2020
A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes1–7.
PCAWG Structural Variation Working Group, PCAWG Consortium   +1 more
core   +1 more source

Identification of gene family members and a key structural variation reveal important roles of OVATE genes in regulating tea (Camellia sinensis) leaf development

Frontiers in Plant Science, 2022
OVATE genes are a new class of transcriptional repressors with important regulatory roles in plant growth and development. Through genome-wide analysis of the OVATE gene family of tea plants, 26 and 13 family members were identified in cultivated and ...
Yanlin An, Xiaobo Xia, Tingting Jing, Feng Zhang   +3 more
doaj   +1 more source

Patient-Specific Assays Based on Whole-Genome Sequencing Data to Measure Residual Disease in Children With Acute Lymphoblastic Leukemia: A Proof of Concept Study

Frontiers in Oncology, 2022
Risk-adapted treatment in acute lymphoblastic leukemia (ALL) relies on genetic information and measurable residual disease (MRD) monitoring. In this proof of concept study, DNA from diagnostic bone marrow (BM) of six children with ALL, without ...
Cecilia Arthur, Cecilia Arthur, Fatemah Rezayee, Fatemah Rezayee, Nina Mogensen, Nina Mogensen, Leonie Saft, Leonie Saft, Richard Rosenquist, Richard Rosenquist, Magnus Nordenskjöld, Magnus Nordenskjöld, Arja Harila-Saari, Emma Tham, Emma Tham, Gisela Barbany, Gisela Barbany   +16 more
doaj   +1 more source

Ten new high-quality genome assemblies for diverse bioenergy sorghum genotypes

Frontiers in Plant Science, 2023
IntroductionSorghum (Sorghum bicolor (L.) Moench) is an agriculturally and economically important staple crop that has immense potential as a bioenergy feedstock due to its relatively high productivity on marginal lands.
William G. Voelker, William G. Voelker, Krittika Krishnan, Krittika Krishnan, Kapeel Chougule, Louie C. Alexander, Louie C. Alexander, Zhenyuan Lu, Andrew Olson, Doreen Ware, Doreen Ware, Kittikun Songsomboon, Kittikun Songsomboon, Cristian Ponce, Cristian Ponce, Zachary W. Brenton, Zachary W. Brenton, J. Lucas Boatwright, J. Lucas Boatwright, Elizabeth A. Cooper, Elizabeth A. Cooper   +20 more
doaj   +1 more source

Structural variation in the chicken genome identified by paired-end next-generation DNA sequencing of reduced representation libraries [PDF]

, 2011
Background Variation within individual genomes ranges from single nucleotide polymorphisms (SNPs) to kilobase, and even megabase, sized structural variants (SVs), such as deletions, insertions, inversions, and more complex rearrangements.
Kerstens Hindrik HD, Vereijken, A., Martien AM Groenen, Bert W Dibbits, Groenen, M.A.M., Dibbits, B.W., Kerstens, H.H.D., Dibbits Bert W, Okimoto Ron, Hindrik HD Kerstens, Richard PMA Crooijmans, Addie Vereijken, Vereijken Addie, Crooijmans, R.P.M.A., Okimoto, R., Groenen Martien AM, Crooijmans Richard PMA, Ron Okimoto   +17 more
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Complete Genome Sequence Reveals Evolutionary and Comparative Genomic Features of Xanthomonas albilineans Causing Sugarcane Leaf Scald

Microorganisms, 2020
Leaf scald (caused by Xanthomonas albilineans) is an important bacterial disease affecting sugarcane in most sugarcane growing countries, including China. High genetic diversity exists among strains of X. albilineans from diverse geographic regions.
Hui-Li Zhang, Mbuya Sylvain Ntambo, Philippe C. Rott, Gongyou Chen, Li-Lan Chen, Mei-Ting Huang, San-Ji Gao   +6 more
doaj   +1 more source

Global whole-genome comparison and analysis to classify subpopulations and identify resistance genes in weedy rice relevant for improving crops

Frontiers in Plant Science, 2023
Common weedy rice plants are important genetic resources for modern breeding programs because they are the closest relatives to rice cultivars and their genomes contain elite genes.
Zhenyun Han, Fei Li, Weihua Qiao, Weihua Qiao, Xiaoming Zheng, Xiaoming Zheng, Xiaoming Zheng, Yunlian Cheng, Lifang Zhang, Jingfen Huang, Yanyan Wang, Danjing Lou, Meng Xing, Weiya Fan, Yamin Nie, Wenlong Guo, Shizhuang Wang, Ziran Liu, Qingwen Yang, Qingwen Yang   +19 more
doaj   +1 more source