Results 31 to 40 of about 691,412 (269)

Cognitive Functioning in Vorinostat‐Treated Pediatric and Young Adult Patients Over the First 180 Days After Hematopoietic Stem Cell Transplant

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Cognitive and psychological difficulties could negatively interfere with treatment adherence and quality of life before and after hematopoietic stem cell transplant (HSCT). Methods to mitigate these changes may have positive effects on treatment success.
Kristen L. Votruba, Michelle Rozwadowski, Thomas Braun, April Rahrig, Edward Peres, Kirsten M. Williams, Vanessa Fabrizio, Julie‐An Talano, Carrie L. Kitko, Nicolas Parnell, Pavan Reddy, Sung Won Choi   +11 more
wiley   +1 more source

Impact and characterization of serial structural variations across humans and great apes

Nature Communications
Modern sequencing technology enables the systematic detection of complex structural variation (SV) across genomes. However, extensive DNA rearrangements arising through a series of mutations, a phenomenon we refer to as serial SV (sSV), remain ...
Wolfram Höps, Tobias Rausch, Michael Jendrusch, Human Genome Structural Variation Consortium (HGSVC), Jan O. Korbel, Fritz J. Sedlazeck   +5 more
doaj   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

Evolutionary conservation and enhanced basal immunity of the ZmNBS gene family in maize

Frontiers in Plant Science
The nucleotide-binding site (NBS) gene family is central to plant innate immunity. However, a comprehensive understanding of its evolutionary dynamics and functional diversity in maize, particularly within a pan-genomic context, remains limited.
Zhe Xu, Liying Feng
doaj   +1 more source

Second harmonic generation polarization microscopy as a tool for protein structure analysis

Biophysics and Physicobiology, 2019
Cryo-electron microscopy and X-ray crystallography have been the major tools of protein structure analysis for decades and will certainly continue to be essential in the future.
Junichi Kaneshiro, Yasushi Okada, Tomohiro Shima, Mika Tsujii, Katsumi Imada, Taro Ichimura, Tomonobu M. Watanabe   +6 more
doaj   +1 more source

SINE Insertion in the Intron of Pig GHR May Decrease Its Expression by Acting as a Repressor

Animals, 2021
The genetic diversity of the GH/IGF axis genes and their association with the variation of gene expression and phenotypic traits, principally represented by SNPs, have been extensively reported.
Cai Chen, Yao Zheng, Mengli Wang, Eduard Murani, Enrico D’Alessandro, Ali Shoaib Moawad, Xiaoyan Wang, Klaus Wimmers, Chengyi Song   +8 more
doaj   +1 more source

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Long-read sequencing reveals novel structural variation markers for key agronomic and quality traits of food-grade soybean

Frontiers in Plant Science
Long read sequencing has been widely used to detect structure variations that are not captured by short read sequencing in plant genomic research.
Zhibo Wang, Kassaye Belay, Kassaye Belay, Joe Paterson, Patrick Bewick, William Singer, Qijian Song, Bo Zhang, Song Li   +8 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

MATCHCLIP: Locate precise breakpoints for copy number variation using CIGAR string by matching soft clipped reads

Frontiers in Genetics, 2013
Copy number variations (CNVs) are associated with many complex diseases. Next generation sequencing data enable one to identify precise CNV breakpoints to better under the underlying molecular mechanisms and to design more efficient assays.
Yinghua eWu, Lifeng eTian, Mario ePirastu, Dwight eStambolian, Hongzhe eLi   +4 more
doaj   +1 more source