Results 51 to 60 of about 691,412 (269)

Genome-wide association analyses reveal copy number variant regions associated with reproduction and disease traits in Canadian Holstein cattle

Journal of Dairy Science
: This study aimed to evaluate the impact of copy number variants (CNV) on 13 reproduction and 12 disease traits in Holstein cattle. Intensity signal files containing log R ratio and B allele frequency information from 13,730 Holstein animals genotyped ...
Hinayah Rojas de Oliveira, Tatiane C.S. Chud, Gerson A. Oliveira, Jr., Isis C. Hermisdorff, Saranya G. Narayana, Christina M. Rochus, Adrien M. Butty, Francesca Malchiodi, Paul Stothard, Filippo Miglior, Christine F. Baes, Flavio S. Schenkel   +11 more
doaj   +1 more source

Patient-Specific Assays Based on Whole-Genome Sequencing Data to Measure Residual Disease in Children With Acute Lymphoblastic Leukemia: A Proof of Concept Study

Frontiers in Oncology, 2022
Risk-adapted treatment in acute lymphoblastic leukemia (ALL) relies on genetic information and measurable residual disease (MRD) monitoring. In this proof of concept study, DNA from diagnostic bone marrow (BM) of six children with ALL, without ...
Cecilia Arthur, Cecilia Arthur, Fatemah Rezayee, Fatemah Rezayee, Nina Mogensen, Nina Mogensen, Leonie Saft, Leonie Saft, Richard Rosenquist, Richard Rosenquist, Magnus Nordenskjöld, Magnus Nordenskjöld, Arja Harila-Saari, Emma Tham, Emma Tham, Gisela Barbany, Gisela Barbany   +16 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Complete Genome Sequence Reveals Evolutionary and Comparative Genomic Features of Xanthomonas albilineans Causing Sugarcane Leaf Scald

Microorganisms, 2020
Leaf scald (caused by Xanthomonas albilineans) is an important bacterial disease affecting sugarcane in most sugarcane growing countries, including China. High genetic diversity exists among strains of X. albilineans from diverse geographic regions.
Hui-Li Zhang, Mbuya Sylvain Ntambo, Philippe C. Rott, Gongyou Chen, Li-Lan Chen, Mei-Ting Huang, San-Ji Gao   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A re-sequencing based assessment of genomic heterogeneity and fast neutron-induced deletions in a common bean cultivar

Frontiers in Plant Science, 2013
A small fast neutron mutant population has been established from Phaseolus vulgaris cv. Red Hawk. We leveraged the available P. vulgaris genome sequence and high throughput next generation DNA sequencing to examine the genomic structure of five ...
Jamie A. O'Rourke, Jamie A. O'Rourke, Luis P. Iniguez, Bruna eBucciarelli, Bruna eBucciarelli, Jeffrey eRoessler, Jeremy eSchmutz, Phillip E. McClean, Scott A. Jackson, Georgina eHernandez, Michelle A. Graham, Robert M. Stupar, Carroll P. Vance, Carroll P. Vance   +13 more
doaj   +1 more source

Exploring the Relationship Among Divergence Time and Coding and Non-coding Elements in the Shaping of Fungal Mitochondrial Genomes

Frontiers in Microbiology, 2020
The order Hypocreales (Ascomycota) is composed of ubiquitous and ecologically diverse fungi such as saprobes, biotrophs, and pathogens. Despite their phylogenetic relationship, these species exhibit high variability in biomolecules production, lifestyle,
Paula L. C. Fonseca, Fernanda Badotti, Ruth B. De-Paula, Daniel S. Araújo, Dener E. Bortolini, Luiz-Eduardo Del-Bem, Luiz-Eduardo Del-Bem, Vasco A. Azevedo, Bertram Brenig, Eric R. G. R. Aguiar, Aristóteles Góes-Neto, Aristóteles Góes-Neto   +11 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source