Results 71 to 80 of about 3,751,240 (350)
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Structuralism in architecture: a definition
Journal of Aesthetics & Culture, 2011 What structuralism in architecture aimed at has often been misunderstood. Structuralism was not about democracy, giving the users of a building the possibility to make changes in it.
Lisbeth Söderqvist
doaj +1 more source
Judging the Law of Politics [PDF]
, 2005 In this Review Essay I explore the rights-structure debate that has captivated the attention of election law scholars. The Essay juxtaposes the recent work of a leading individualist Professor Richard Hasen\u27s new book, The Supreme Court and Election ...
Charles, Guy-Uriel
core +2 more sources
Notre Dame Journal of Formal Logic, 1991 The authors investigate a calculus of individuals based on a primitive notion of connectedness. They show that their system of axioms leads to complete orthocomplemented lattices whereas the extension of their system to the Clarke system leads to complete atomless Boolean algebras [see also \textit{B. Clarke}, ibid. 26, 61-75 (1985; Zbl 0597.03005)].
Biacino, Loredana, Gerla, Giangiacomo
openaire +4 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Symmetries and Paraparticles as a Motivation for Structuralism [PDF]
, 2009 This paper develops an analogy proposed by Stachel between general relativity (GR) and quantum mechanics (QM) as regards permutation invariance. Our main idea is to overcome Pooley's criticism of the analogy by appeal to paraparticles.
Butterfield, Jeremy, Caulton, Adam
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Studi Perbandingan Paradigma Fungsionalisme Structural VS Strukturalisme Levi-Strauss
Asketik, 2018 This study aims to compare two paradigms functional paradigm (structural) vs. structuralism Levi-Strauss. To answer questions about both these paradigms will use a comparative study between functionalism paradigm theory or functionalism (structural) and ...
Intan Sari Devi
doaj +1 more source
From structuralism to poststructuralism [PDF]
, 2013 As the immediate precursor to poststructuralism, the movement or paradigm of structuralism was naturally responsible for determining many of poststructuralism’s salient features. But what was structuralism, and how are we to understand its transformation
Lundy, C
core
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source