Results 171 to 180 of about 946,828 (294)

CCR3 antagonists: a potential new therapy for the treatment of asthma. Discovery and structure–activity relationships

, 2002
Dean A. Wacker, Joseph B. Santella, Daniel S. Gardner, Jeffrey Varnes, Melissa Estrella, George V. Delucca, Soo S. Ko, Keiichi Tanabe, Paul S. Watson, Patricia K. Welch, Maryanne Covington, Nicole Stowell, Eric Wadman, Paul Davies, Kimberly A. Solomon, Robert Newton, George L. Trainor, Steven Friedman, Carl P. Decicco, John V. Duncia   +19 more
openalex   +1 more source

Current development of 1,2,3-triazole derived potential antimalarial scaffolds: Structure- activity relationship (SAR) and bioactive compounds

, 2023
S. Maheen Abdul Rahman, Jasvinder Singh Bhatti, Suresh Thareja, Vikramdeep Monga   +3 more
openalex   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

New Structure Activity Relationship Insight into the Role of the C-3 Extension on Rifamycin Antimycobacterial Activity. [PDF]

ChemMedChem
Veale CGL, Smolarz E, Leśniewska A, Pyta K, Przybylski P.   +4 more
europepmc   +1 more source

Modeling of p-aminophenol compounds as analgesic antiinflammatory based on biologic activity and structure relationship

, 2011
Pudjono, Sri Sutji Susilowati, Rehana
openalex   +2 more sources

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Machine Learning-Enhanced Quantitative Structure-Activity Relationship Modeling for DNA Polymerase Inhibitor Discovery: Algorithm Development and Validation. [PDF]

JMIR AI
Kakraba S, Ayyadevara S, Yadem Clement A, Abraham KE, Compadre CM, Shmookler Reis RJ.   +5 more
europepmc   +1 more source

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

Arthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source

Design, synthesis and structure-activity relationship analysis of dibenzodiazepinone derivatives against Osimertinib resistant NSCLC. [PDF]

RSC Med Chem
Jin C, Zhang Z, Liao P, Zhang C, Cao H, Ma YL.   +5 more
europepmc   +1 more source

Mechanism in Bioconcentration of Organic Chemicals in Fish and its Structure-Activity Relationship.

, 1993
Tsutomu Nishihara, Shoji Saito, Masatoshi Matsuo   +2 more
openalex   +2 more sources