Results 81 to 90 of about 1,309,636 (359)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Design and production of educational content for students with special needs in the e-learning [PDF]

Journal of Distance Learning and Open Learning, 2014
Many of our educational institutions have become in our time environments electronic learning on the Internet, and also became absolutely necessary for all developed societies and developing alike, especially in light of the rapid and quick modern ...
عزة شحاتة
doaj   +1 more source

Counselling immigrant adults at an educational institution [PDF]

, 2005
The principle of promoting free mobility of citizens has been written into European educational policies. Additionally, the philosophy of educational equality has been clearly included into the educational regulation of most European countries ...
Clayton, P., Kaikkonen, L., Maunonen-Eskelinen, I.   +2 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Harnessing artificial intelligence for inclusive education management: Strategies for supporting students with special needs

Journal of Educational Management and Instruction
Inclusive education aims to provide equitable learning opportunities for all students, including those with special needs, yet its implementation faces challenges such as limited resources and curriculum adaptation.
M. Ary Irawan, Zul Anwar
doaj   +1 more source

'Looking back, looking forward': An interview with Emeritus Professor Ted Glynn on his involvement in special education [PDF]

, 2012
In interview with Dr Peter Stanley, Professor Glynn reflects on how he became involved in special education, and on his work with the Pause Prompt Praise reading strategy, the Mangere Guidance and Learning Unit (which gave rise to Guidance and Learning ...
Glynn, Ted, Stanley, Peter
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Special Education 2000 : the implementation experience : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Social Policy at Massey University [PDF]

, 2003
Since 1877 the state has provided free, secular and compulsory education for most of the children of school age in New Zealand. In 1989 legislation was passed that gave the right to enrol and attend at the local school to all children.
Wills, Roderick Malcolm Campbell
core  

MATHEMATICS DISPOSITIONS OF SECONDARY SCHOOL STUDENTS WITH SPECIAL EDUCATIONAL NEEDS [PDF]

Journal of Research in Special Educational Needs, 2016
The aim of this paper was to shed more light on the attitudes and dispositions to mathematics education of secondary school students with special educational needs ( SEN ) in mainstream schools.
Kalambouka, Afroditi, Pampaka, Maria, Omuvwie, Michael, Wo, Lawrence   +3 more
openaire   +2 more sources