Results 81 to 90 of about 34,885 (296)

Dataset Homarus electrical stunning [Dataset]

This study tested the feasibility of using the Crustastun™ device to stun the American lobster (Homarus americanus) in order to: (i) Determine the effect of the stunning duration on the recovery and behaviour; (ii) Asses physiological disturbances caused
García, José A., Chic, Óscar, Font-i-Furnols, Maria, Rotllant, Guiomar, Lorenzo, Rodrigo, González, Joel, Llonch, Pol   +6 more
core   +1 more source

Microbiological quality during postmortem aging periods of semitendinosus muscle in goat subjected to slaughter without stunning and slaughter following different methods of electrical stunning.

, 2016
Graphs A-D: the population of total aerobic counts, Pseudomonas spp., lactic acid bacteria and Enterobacteriaceae, respectively. SWS: slaughter without stunning, LFHO: low frequency head-only, electrical stunning, LFHB: low frequency head-to-back ...
Mohd Zainal Abidin Ab Kadir (2586322), Awis Qurni Sazili (2586331), Ubedullah Kaka (2586334), Yong Meng Goh (2586316), Azad Behnan Sabow (2586310), Jurhamid Columbres Imlan (2586328), Ahmed Abubakar Abubakar (2586325), Idrus Zulkifli (2586313), Kazeem Dauda Adeyemi (2586319)   +8 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Stunning challenges: operational indicators flag failures, but neurological validation is needed to confirm stunning effectiveness in seabass and seabream

Humane slaughter in aquaculture depends on accurate assessments of insensibility, yet commonly used operational indicators remain poorly validated against neurological benchmarks. This study compared operational indicators such as the loss or recovery of
Cabrera-Álvarez, María José, Saraiva, João, Brijs, Jeroen, Oliveira, Gonçalo, Arechavala-Lopez, Pablo, Gräns, Albin, Schwerte, Thorsten, Bortoletti, Martina, Saraiva, João L., Sveriges lantbruksuniversitet., Oliveira, Gonçalo D.C., Cabrera-Álvarez, María J., Swedish University of Agricultural Sciences., Gräns, Albin,, Oliveira, Goncalo D. C.   +14 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Assessment of unconsciousness in pigs during exposure to nitrogen and carbon dioxide mixtures

Animal, 2013
The aim of this study was to assess unconsciousness in pigs during and after the exposure to gas mixtures of 70% nitrogen (N2) and 30% carbon dioxide (CO2) (70N30C), 80% N2 and 20% CO2 (80N20C) and 85% N2 and 15% CO2 (85N15C) compared with 90% CO2 in air
P. Llonch, P. Rodríguez, M. Jospin, A. Dalmau, X. Manteca, A. Velarde   +5 more
doaj   +1 more source