Results 71 to 80 of about 28,805 (298)

Blood loss in goats subjected to slaughter without stunning and slaughter following different methods of electrical stunning.

open access: yes, 2016
SWS: slaughter without stunning, LFHO: low frequency head-only, electrical stunning, LFHB: low frequency head-to-back electrical stunning, HFHB: high frequency head-to-back electrical stunning.
Mohd Zainal Abidin Ab Kadir (2586322)   +8 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

EFFECT OF PERIHARVEST HANDLING ON WELFARE STATUS OF SLAUGHTER PIGS AND INTRINSIC PORK QUALITY. REVIEW OF RECENT FINDINGS

open access: yesScientific Papers Animal Science and Biotechnologies, 2023
There is a growing concern of consumers that the meat producing animals are bred, reared, handled and slaughtered in ways that are sympathetic to their welfare status.
E. SZÜCS   +3 more
doaj  

Effect of Two Different Stunning Methods on the Quality Traits of Rabbit Meat

open access: yesAnimals, 2020
The aim of the study was to assess the effect of two different stunning methods on the level of blood stress indicators (cortisol, insulin, glucose) and rabbit meat quality.
Joanna Składanowska-Baryza   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Effectiveness of two methods for stunning pigs: electrical stunning head-heart and CO2 stunning

open access: yesRevista de Investigaciones Veterinarias del Perú, 2017
Los objetivos de este estudio fueron evaluar y comparar la efectividad de los métodos de aturdimiento eléctrico de tres puntos (MA1) y de narcosis con dióxido de carbono (CO2) (MA2) , así como evaluar la infraestructura y manejo de los cerdos en dos plantas de sacrificio comercial de Colombia.
Acevedo-Giraldo, Juan David   +2 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

A stunning experience

open access: yes, 2014
‘A Stunning Experience’ pits Oprah Winfrey and David Letterman against each other in an infinite interview. Through simple editing and compositing, both parties are rendered mute, positioned at either edge of a black void.
McKewen, Daniel
core  

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