Results 51 to 60 of about 28,805 (298)

Stunning pigs with nitrogen and carbon dioxide mixtures: effects on animal welfare and meat quality

Animal, 2012
The aim of this study was to assess the effect of exposure to the gas mixtures of 70% nitrogen (N2) and 30% carbon dioxide (CO2; 70N30C), 80% N2 and 20% CO2 (80N20C) and 85% N2 and 15% CO2 (85N15C) on aversion, stunning effectiveness and carcass, as well
P. Llonch, P. Rodríguez, M. Gispert, A. Dalmau, X. Manteca, A. Velarde   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Unnecessary suffering during the slaughter of cattle and pigs: mapping stun quality and associations to stun-to-stick intervals

Frontiers in Animal Science
Ensuring that animals remain unconscious and insensible until death occurs via blood loss is critical for animal welfare at slaughter. Two key factors are the rapid sticking procedure following stunning and a correct assessment of stunning efficiency ...
Josefine Jerlström, Charlotte Berg, Anna Wallenbeck   +2 more
doaj   +1 more source

Myocardial stunning in hyperthyroidism [PDF]

Clinical Cardiology, 2000
AbstractThe cases of two patients with hyperthyroidism and acute left ventricular (LV) dysfunction with segmental wall motion abnormalities resulting in heart failure are reported. Both had electrocardiographic changes mimicking ischemic coronary artery disease.
N, Pereira, A, Parisi, G W, Dec, J, Choo, R, Hajjar, P C, Gordon   +5 more
openaire   +2 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Scientific Opinion on monitoring procedures at slaughterhouses for poultry

EFSA Journal, 2013
This scientific opinion proposes toolboxes of welfare indicators, and their corresponding outcomes of consciousness, unconsciousness or death, for developing monitoring procedures at slaughterhouses for poultry stunned using electrical waterbaths and gas
EFSA Panel on Animal Health and Welfare (AHAW)
doaj   +1 more source

Harvest Method Influences Color Stability of Longissimus Lumborum Steaks from Bos indicus Cattle

Meat and Muscle Biology, 2019
Brazil is a major beef exporter to countries where religious slaughter without stunning is mandatory. Fresh beef color influences consumers’ purchase decisions, and harvest method influences beef quality attributes, such as color, water holding capacity,
Ana Paula A. A. Salim, Anna C. V. C. S. Canto, Carlos A. Conte-Junior, Fernanda M. Viana, Maria Lucia G. Monteiro, Pedro H. N. Panzenhagen, Surendranath P. Suman   +6 more
doaj   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Feasibility of Animal-Based Indicators of Consciousness and Unconsciousness for Stunning in Sheep: A Systematic Review

Animals, 2023
Background: According to EU legislation, animal-based indicators (ABMs) are used to evaluate the efficacy of stunning methods to ensure that animals do not regain consciousness.
Marta Comin, Sara Barbieri, Michela Minero, Emanuela Dalla Costa   +3 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source