Results 41 to 50 of about 34,885 (296)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Géographie et Cultures, 2020 Mandatory since the mid-1960s, "humanitarian" methods of slaughtering farmed animals became widespread in French slaughterhouses in the second half of the 20th century, in parallel with the meat market modernization process.
Félix Jourdan
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Haematological changes to assess stress arising from different methods of slaughtering in pigs
Indian Journal of Animal SciencesThis study aimed to investigate the blood profile and neutrophil and lymphocyte ratio (NLR) in pigs subjected to stunning and non-stunning. Forty pigs, aged between 6-8 months and weighing 80-100 kg, were used to assess haematological changes associated
I WAYAN SUARDANA +2 more
doaj +1 more source
Animal, 2009 In the present study, the effect of type of stunning (electrical v. gas) and the gas mixtures in a modified atmosphere (MA) packing system (MA-A: 30% CO2 + 70% O2; MA-B: 30% CO2 + 69.3% N2 + 0.7% CO; MA-C: 40% CO2 + 60% N2) on light lamb meat quality ...
M.B. Linares, H. Vergara
doaj +1 more source
Cardiac Arrest Stunning of Livestock and Poultry [PDF]
, 1985 A stunning method that will reliably render an animal insensible to pain and sensation prior to hoisting and bleeding is essential to prevent suffering. Cardiac arrest stunning is more effective than conventional electric stunning.
Grandin, Temple
core
Mechanisms of Myocardial Stunning in Stress-Induced Cardiomyopathy [PDF]
, 2022 Stress-induced cardiomyopathy, in contrast to acute myocardial infarction, is a type of acute heart failure characterized by reversible left ventricular dysfunction.
Lina Zou +10 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Frontiers in Animal ScienceEnsuring that animals remain unconscious and insensible until death occurs via blood loss is critical for animal welfare at slaughter. Two key factors are the rapid sticking procedure following stunning and a correct assessment of stunning efficiency ...
Josefine Jerlström +2 more
doaj +1 more source