Results 61 to 70 of about 153,139 (299)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Contrasting the Employment of Single Mothers and People with Disabilities [PDF]

, 2003
The transition of single women with children off the welfare rolls and into employment (see Figures 1 and 2) in the 1990s has been described as “stunning” by leading policy researchers (see, for instance, Blank 2002).
Burkhauser, Richard V, Stapleton, David C   +1 more
core   +4 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Feasibility of Animal-Based Indicators of Consciousness and Unconsciousness for Stunning in Sheep: A Systematic Review

Animals, 2023
Background: According to EU legislation, animal-based indicators (ABMs) are used to evaluate the efficacy of stunning methods to ensure that animals do not regain consciousness.
Marta Comin, Sara Barbieri, Michela Minero, Emanuela Dalla Costa   +3 more
doaj   +1 more source

You No Real Man : Constructing Gender, Sexuality, and the Asian American Subject in Jana Monji\u27s Kim [PDF]

, 2013
Jana Monji\u27s short story Kim offers a stunning plot twist that challenges readers initial interpretations of the characters as well as many assumptions and stereotypes about Asian American identity, gender, sexuality, and culture.
Field, Robin E.
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Welfare of horses at slaughter

EFSA Journal
The objective of this Scientific Opinion is to assess the hazards and welfare consequences associated with the slaughter of horses for human consumption.
EFSA Panel on Animal Health and Welfare (AHAW), Søren Saxmose Nielsen, Julio Alvarez, Anette Boklund, Sabine Dippel, Fernanda Dorea, Jordi Figuerola, Mette Herskin, Miguel Angel Miranda Chueca, Eleonora Nannoni, Romolo Nonno, Anja Riber, Karl Stahl, Jan Arend Stegeman, Hans‐Hermann Thulke, Frank Tuyttens, Christoph Winckler, Mohan Raj, Antonio Velarde, Denise Candiani, Yves Van der Stede, Virginie Michel   +21 more
doaj   +1 more source

Kneadings, Symbolic Dynamics and Painting Lorenz Chaos. A Tutorial

, 2012
A new computational technique based on the symbolic description utilizing kneading invariants is proposed and verified for explorations of dynamical and parametric chaos in a few exemplary systems with the Lorenz attractor.
Abad A., Afraimovich V., Afraimovich V., ANDREY SHILNIKOV, Barrio R., Barrio R., Bykov V. V., Glendinning P., Gonchenko S. V., Hubner U., LEONID SHILNIKOV, Malkin M., ROBERTO BARRIO, Roshchin N., Rychlic M., Shilnikov A., Shilnikov L., Shilnikov L., Shilnikov L., Shilnikov L. P.   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effects of stunning methods on pre rigor changes in rainbow trout (Oncorhynchus mykiss) reared at two different temperatures

Italian Journal of Animal Science, 2020
The effects of two stunning methods (carbon monoxide asphyxia, CO, and electroshock, E) on blood plasma parameters, rigor index, fillet pH and shape changes, ATP breakdown and Adenylate Energy Charge (AEC) in muscle immediately post mortem were ...
Anna Concollato, Giulia Secci, Antonella Dalle Zotte, Sheyla Cristina Vargas, Rolf Erik Olsen, Adja Cristina Lira de Medeiros, Giuliana Parisi   +6 more
doaj   +1 more source