A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes. [PDF]
Sci Rep, 2017 Whole cell responses arise from coordinated interactions between diverse human gene products functioning within various pathways underlying sub-cellular processes (SCP).
Hansen J +4 more
europepmc +3 more sources
Influence of energy deficiency on the subcellular processes of Substantia Nigra Pars Compacta cell for understanding Parkinsonian neurodegeneration. [PDF]
Sci Rep, 2021 Muddapu VR, Chakravarthy VS.
europepmc +2 more sources
Biophysics and Physicobiology, 2023 Rhodopsins have been extensively employed for optogenetic regulation of bioelectrical activity of excitable cells and other cellular processes across biological systems. Various strategies have been adopted to attune the cellular processes at the desired
Kumari Sushmita +3 more
doaj +1 more source
Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms [PDF]
, 2022 The living cell contains dynamic, spatially complex subassemblies that are sensitive to external perturbations. To minimize such perturbations, cells should be imaged in their native multicellular environments, under as gentle illumination as possible ...
Kirchhausen, Tom +26 more
core +2 more sources
Mathematics, 2023 Long non-coding RNAs (lncRNA) are a class of RNA transcripts with more than 200 nucleotide residues. LncRNAs play versatile roles in cellular processes and are thus becoming a hot topic in the field of biomedicine.
Jianyi Lyu +3 more
doaj +1 more source
A spatially specified systems pharmacology therapy for axonal recovery after injury [PDF]
, 2023 There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that ...
Vera Rabinovich +16 more
core +1 more source
Novel Reporter for Faithful Monitoring of ERK2 Dynamics in Living Cells and Model Organisms. [PDF]
PLoS ONE, 2015 Uncoupling of ERK1/2 phosphorylation from subcellular localization is essential towards the understanding of molecular mechanisms that control ERK1/2-mediated cell-fate decision.
François Sipieter +8 more
doaj +1 more source
tRNA processing, modification, and subcellular dynamics: past, present, and future [PDF]
RNA, 2015 tRNA research was such a small field in 1995 that we used to quip that we could have a meeting of the entire American community interested in tRNA processing and modification in one of our living rooms. Research since the 1960's had yielded the crucial role of tRNAs in translation, and contributed heavily to our understanding of RNA structure and ...
Phizicky, Eric M., Hopper, Anita K.
openaire +2 more sources
Novel application of fluorescence lifetime and fluorescence microscopy enables quantitative access to subcellular dynamics in plant cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Optical and spectroscopic technologies working at subcellular resolution with quantitative output are required for a deeper understanding of molecular processes and mechanisms in living cells.
Kirstin Elgass +5 more
doaj +1 more source
Predicting Protein Subcellular Location Using Digital Signal Processing [PDF]
Acta Biochimica et Biophysica Sinica, 2005 The biological functions of a protein are closely related to its attributes in a cell. With the rapid accumulation of newly found protein sequence data in databanks, it is highly desirable to develop an automated method for predicting the subcellular location of proteins.
Yu-Xi, Pan +6 more
openaire +2 more sources