Results 111 to 120 of about 7,584 (205)

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice

BMC Musculoskeletal Disorders, 2017
Background Subchondral osteopenia is important for the pathophysiology of osteoarthritis (OA). Although previous studies suggest that plasminogen activator inhibitor-1 (PAI-1), an inhibitor of fibrinolysis, is related to bone metabolism, its role in OA ...
Akihiro Moritake, Naoyuki Kawao, Kiyotaka Okada, Kohei Tatsumi, Masayoshi Ishida, Katsumi Okumoto, Osamu Matsuo, Masao Akagi, Hiroshi Kaji   +8 more
doaj   +1 more source

Osteoarthritis alters the patellar bones subchondral trabecular architecture [PDF]

Journal of Orthopaedic Research, 2016
Sebastian Hoechel, Hans Deyhle, Mireille Toranelli, Magdalena Müller-Gerbl   +3 more
openaire   +1 more source

The functional morphology of subchondral and trabecular bone in the hominoid tibiotalar joint

, 2011
This dissertation investigated whether the internal bone morphology of the distal tibia and talus may help to further clarify the controversial mosaics of external morphological traits previously found in fossil hominin ankle bones that have suggested ...
Su, Anne
core  

Scaffold-Guided Subchondral Bone Repair

, 2010
Background: Microfracture and drilling elicit a cartilage repair whose quality depends on subchondral bone repair. Alternatively activated (AA) macrophages express arginase-1, release angiogenic factors, and could be potential mediators of trabecular ...
Anik Chevrier, Marchand, Catherine, Gaoping Chen, Sun, Jun, Caroline D. Hoemann, El-Gabalawy, Hani, Marc Thibault, Maria J. G. Fernandes, Matthew S. Shive, Hani El-Gabalawy, Poubelle, Patrice E., Centola, Michael, Patrice E. Poubelle, Michael Centola, Thibault, Marc, Shive, Matthew S., Fernandes, Maria J. G., Nicolas Tran-Khanh, Hoemann, Caroline D., Tran-Khanh, Nicolas, Chevrier, Anik, Jun Sun, Chen, Gaoping, Catherine Marchand   +23 more
core   +1 more source

Multiscale characterisation of subchondral trabecular bone changes in the osteoarthritic ankle [PDF]

, 2021
An increasingly younger population are seeking treatment for osteoarthritis of the ankle. Current late-stage surgical interventions sacrifice the upper levels of the distal tibia and talus to allow for joint replacement implantation.
Koria, Lekha Laxmi Harish
core  

Treatment of osteoarthritis by implantation of Mg- and WE43-cylinders - A preclinical study on bone and cartilage changes and their influence on pain sensation in rabbits

Bioactive Materials
With its main features of cartilage degeneration, subchondral bone sclerosis and osteophyte formation, osteoarthritis represents a multifactorial disease with no effective treatment options.
Nina Angrisani, Christin von der Ahe, Regine Willumeit-Römer, Henning Windhagen, Verena Scheper, Michael Schwarze, Björn Wiese, Heike Helmholz, Janin Reifenrath   +8 more
doaj   +1 more source

Effect of internal heat-type acupuncture needle on the expression of osteoprotegerin, receptor activator of NF-κB ligand and receptor activator of NF-κB of subchondral bone in knee osteoarthritis rabbits

针刺研究, 2021
Objective To investigate the effect of internal heat-type acupuncture needle on the expression of osteoprotegerin(OPG), receptor activator of NF-κB ligand(RANKL), and receptor activator of NF-κB(RANK) in knee osteoarthritis(KOA) rabbits, so as to explore
HEI Xiao-yan, XU Jian-feng, ZHU Shi-qiang, TIAN Xin-bao, ZHANG Jin-chen, CHEN Yun-dong, LIN Rui-zhu   +6 more
doaj  

Properties of growing trabecular ovine bone

, 2000
We aimed to highlight the relationship between age and the architectural properties of trabecular bone, to outline the patterns in which the variations in these properties take place, and to investigate the influence of the architecture on the ...
A. Odgaard, F. Linde, J. Kabel, A. Nafei, I. Hvid   +4 more
core   +1 more source

In vivo impact on rabbit subchondral bone of viscosupplementation with a hyaluronic acid antioxidant conjugate

BMC Musculoskeletal Disorders
Objective This study aimed to assess the effects of an antioxidant-conjugated Hyaluronic Acid (HA), specifically HA-4-aminoresorcinol (HA4AR), on articular cartilage and subchondral bone in osteoarthritis (OA). We conducted a comparative analysis between
R. Rieger, S. Kaderli, C. Boulocher
doaj   +1 more source