Results 91 to 100 of about 7,584 (205)

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Subchondral bone.

, 2022
Two-way ANOVA was used to assess the effects of surgery (control vs. surgery destabilizing the medial meniscus [DMM]) and genotype (Wnt16flox/flox vs. Cre-Wnt16flox/flox) on bone parameters. There was no effect on the total medial subchondral bone volume/
Lei Li (29537), Claes Ohlsson (1924), Sofia Movérare-Skrtic (88204), Karin H. Nilsson (14106647), Anna E. Törnqvist (14106644)   +4 more
core   +1 more source

Effect of early intra ⁃ articular injection of alendronate in reducing subchondral bone loss in rat mandibular condyle after ovariectomy

口腔疾病防治, 2017
Objective To investigate the effects of intra⁃articular injection of alendronate on the mandibular condyle in ovariectomized rats. Methods Sixty female rats were randomly divided into five groups: ovariectomy with vehicle treat⁃ ment alone, early ...
ZHU Song⁃ song
doaj   +1 more source

Sustained Hypoxia‐Inducible Factor 1‐Alpha Accumulation Disrupts the Articular Niche to Promote Osteoarthritis Pathogenesis

Aging Cell, Volume 25, Issue 7, July 2026.
Sustained HIF‐1α accumulation is not a compensatory shield, but a potent pathogenic driver of osteoarthritis. Continuous HIF‐1α signaling physically eradicates the avascular cartilage niche and primes the synovium for inflammation, establishing HIF‐1α as a critical target for disease‐modifying therapies.
Weiyuan Gong, Chu Tao, Xingyun Wang, Rongdong Liao, Jianglong Li, Xiongtian Guo, Minghao Qu, Jianmei Huang, Mingjue Chen, Fuxin Wei, Peng Wang, Lijun Lin, Di Chen, Qing Yao, Chunyi Wen, Guozhi Xiao   +15 more
wiley   +1 more source

Multiscale Quantitative Imaging of Human Femoral Heads Using X-ray Microtomography

, 2011
PhDClinical diagnostic tools provide limited information on the underlying structural and mechanical properties of bone-tissue affected by degenerative and bone metabolic diseases.
Ahmed, Farhat
core  

Vertebral Bone Remodeling after Disk Degeneration-Quantitative Microanalysis in a Porcine Nucleotomy Model

Global Spine Journal, 2012
Introduction Changes in vertebral endplate sclerosis and permeability seem to be a crucial aspect in the course of disk degeneration. Detailed information on microstructural changes of the subchondral bone of the endplates and the trabecular vertebral ...
G. Omlor, S. Lorenz, F. Huettner, J. Holschbach, W. Richter, T. Gühring   +5 more
doaj   +1 more source

Lateromedial and oblique radiographs detect most fetlock pathologies as effectively as a full series in horses

Equine Veterinary Journal, Volume 58, Issue 4, Page 934-945, July 2026.
Abstract Background Radiographic protocols for the metacarpo‐/tarsophalangeal joint during pre‐purchase examinations (PPE) vary internationally, but their impact on pathology detection remains unclear. Optimising imaging protocols is essential to balance diagnostic accuracy with workflow efficiency and radiation exposure.
A. Northwood, D. Berner
wiley   +1 more source

Subchondral bone plate integrity is closely associated with subchondral trabecular bone homeostasis in osteoarthritis [PDF]

Osteoarthritis and Cartilage, 2018
G. Li, T. Cheng, N. Pavlos, C. Zhang, M. Zheng   +4 more
openaire   +1 more source

The influence of functional loading on bone remodelling in the human mandible

, 2008
The strain (i.e. deformation) history influences the degree of mineralization of cortical bone (DMB) as well as its osteonal microstructure. This study aimed first to examine the relationships of stress and strain distributions with the variations in DMB
Cioffi, Iacopo
core  

Spatially matching morphometric assessment of cartilage and subchondral bone in osteoarthritic human knee joint with micro-computed tomography

, 2019
© 2018 Objective: The objective of this study was to develop a reproducible and semi-automatic method based on micro computed tomography (microCT) to analyze cartilage and bone morphology of human osteoarthritic knee joints in spatially matching regions ...
Brittberg, Mats,, Gatenholm, Birgitta,, Stadelmann, Vincent A., Lindahl, Carl   +3 more
core   +1 more source