Results 41 to 50 of about 7,584 (205)

Quantitative evaluation of subchondral bone microarchitecture in knee osteoarthritis using 3T MRI

BMC Musculoskeletal Disorders, 2017
Background Osteoarthritis (OA) is now increasingly recognized as being related to the whole joint instead of the cartilage alone. In particular, the importance of subchondral bone in OA pathogenesis has drawn a lot of interest.
Chenglei Liu, Chang Liu, Xvhua Ren, Liping Si, Hao Shen, Qian Wang, Weiwu Yao   +6 more
doaj   +1 more source

Betaine Attenuates Osteoarthritis by Inhibiting Osteoclastogenesis and Angiogenesis in Subchondral Bone

Frontiers in Pharmacology, 2021
Osteoarthritis (OA) is the most common type of arthritis with no effective therapy. Subchondral bone and overlying articular cartilage are closely associated and function as “osteo-chondral unit” in the joint.
Wang Yajun, Cui Jin, Gu Zhengrong, Fang Chao, Hu Yan, Hu Yan, Weng Weizong, Li Xiaoqun, Zhou Qirong, Chen Huiwen, Zhang Hao, Guo Jiawei, Zhuang Xinchen, Sheng Shihao, Wang Sicheng, Wang Sicheng, Chen Xiao, Su Jiacan, Su Jiacan, Su Jiacan   +19 more
doaj   +1 more source

Degradation of subchondral bone collagen in the weight-bearing area of femoral head is associated with osteoarthritis and osteonecrosis

Journal of Orthopaedic Surgery and Research, 2020
Background The aim of the study was to evaluate the change of subchondral bone collagen and trabecular bone in the weight-bearing area of femoral head from patients with osteoarthritis (OA) or osteonecrosis of femoral head (ONFH), and discuss the effect ...
Zongyi Wu, Bingzhang Wang, Jiahao Tang, Bingli Bai, Sheji Weng, Zhongjie Xie, Zijian Shen, Deyi Yan, Liang Chen, Jingdong Zhang, Lei Yang   +10 more
doaj   +1 more source

The quantification of 3D-trabecular architecture of the fourth cervical vertebra using CT osteoabsorptiometry and micro-CT

Journal of Orthopaedic Surgery and Research, 2023
Background Bone functional adaptation rationalises the inhomogeneous morphology found in bone. By means of computed tomography osteoabsorptiometry and micro-computed tomography, the mineralisation of the subchondral endplates and trabecular ...
Amélie Poilliot, Max Hans-Peter Gay-Dujak, Magdalena Müller-Gerbl   +2 more
doaj   +1 more source

Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis

Advanced Science, EarlyView.
This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou, Yongfeng Chen, Longyou Xiao, Wei Qi, Tianshu Du, Qiang Sun, Borui Xue, Qinghe Zhao, Pengfei Xie, Zi Ye, Fei Han, Lingli Guo, Yang Jiao, Ranran Zhang, Hong Jia, Xiao Huang, Jianwei Guo, Peng Wang, Huayi Wang, Yuanrui Wang, Wenjing Chen, Haining Wu, Liumin He, Dawei Zhang   +23 more
wiley   +1 more source

Association between subchondral bone structure and osteoarthritis histopathological grade [PDF]

, 2016
Despite increasing evidence that subchondral bone contributes to osteoarthritis (OA) pathogenesis, little is known about local changes in bone structure compared to cartilage degeneration.
Jari Rautiainen, Virpi Tiitu, Sami Kauppinen, Kauppinen, Sami, Tiitu, Virpi, Pritzker, K. (Kenneth), Jérôme Thevenot, Finnilä, Mikko A. J., Nieminen, Miika T., Lehenkari, P. (Petri), Valkealahti, Maarit, Tiitu, V. (Virpi), Kauppinen, S. (Sami), Thevenot, J. (Jérôme), Kenneth Pritzker, Thevenot, Jérôme, Simo Saarakkala, Petri Lehenkari, Finnilä, M. A. (Mikko A. J.), Miika T. Nieminen, Saarakkala, S. (Simo), Maarit Valkealahti, Olli‐Matti Aho, Saarakkala, Simo, Aho, O.-M. (Olli-Matti), Rautiainen, Jari, Rautiainen, J. (Jari), Mikko A. J. Finnilä, Aho, Olli-Matti, Nieminen, M. T. (Miika T.), Valkealahti, M. (Maarit), Lehenkari, Petri, Pritzker, Kenneth   +32 more
core   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

Trabecular and subchondral bone development of the talus and distal tibia from foal to adult in the warmblood horse [PDF]

Anatomia, Histologia, Embryologia, 2018
SummaryHorses are precocial animals and able to stand and walk within hours after birth. To cope with associated loading, intrauterine bone development has shown to be anticipative. This study provides further insight into the post‐natal development of structurally important features of trabecular and subchondral bone of the talus and sagittal ridge of
B. M. C. Gorissen, C. F. Wolschrijn, B. van Rietbergen, L. Rieppo, S. Saarakkala, P. R. van Weeren   +5 more
openaire   +5 more sources

Quantitative morphology of the subchondral plate of the tibial plateau [PDF]

, 1994
The object of the present investigation was to measure the thickness distribution of the subchondral plate of the tibial plateau. The data were obtained by computerised image analysis of serial sections.
Milz, S., Putz, Reinhard
core  

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source