Results 21 to 30 of about 7,584 (205)

The effect of postmenopausal osteoporosis on subchondral bone pathology in a rat model of knee osteoarthritis

Scientific Reports, 2023
This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis (OP) on the pathology of knee osteoarthritis (OA) in a rat meniscectomized model, particularly focusing on subchondral bone changes and pain behaviour.
Hiroyuki Wada, Koji Aso, Masashi Izumi, Masahiko Ikeuchi   +3 more
doaj   +1 more source

Tibial cartilage, subchondral bone plate and trabecular bone microarchitecture in varus‐ and valgus‐osteoarthritis versus controls [PDF]

Journal of Orthopaedic Research, 2020
AbstractThis preliminary study quantified tibia cartilage thickness (Cart.Th), subchondral bone plate thickness (SBPl.Th) and subchondral trabecular bone (STB) microarchitecture in subjects with varus‐ or valgus‐ malaligned knees diagnosed with end‐stage knee osteoarthritis (OA) and compared them to controls (non‐OA).
Sophie Rapagna, Bryant C. Roberts, Lucian B. Solomon, Karen J. Reynolds, Dominic Thewlis, Egon Perilli   +5 more
openaire   +3 more sources

Subchondral Trabecular Microstructure and Articular Cartilage Damage Variations Between Osteoarthritis and Osteoporotic Osteoarthritis: A Cross-sectional Cohort Study

Frontiers in Medicine, 2021
Osteoporotic osteoarthritis (OP-OA) is a specific type of OA. In this study, we aimed to assess the subchondral plate and rod microstructural differences between OA and OP-OA patients by using an individual trabeculae segmentation (ITS) system and to ...
Feng Zhou, Feng Zhou, Linyang Chu, Linyang Chu, Xuqiang Liu, Zihao He, Xuequan Han, Mengning Yan, Xinhua Qu, Xiaofeng Li, Zhifeng Yu   +10 more
doaj   +1 more source

Does Bisphosphonate Increase the Sclerosis of Tibial Subchondral Bone in the Progression of Knee Osteoarthritis—A Propensity Score Matching Cohort Study Based on Osteoarthritis Initiative

Frontiers in Medicine, 2021
Bisphosphonate has great potential in KOA therapy, but whether the anti-resorption mechanism of bisphosphonate aggravates sclerosis of subchondral bone remains unclear.
Mingyang Li, Yong Nie, Yi Zeng, Yuangang Wu, Yuan Liu, Limin Wu, Jiawen Xu, Bin Shen   +7 more
doaj   +1 more source

Morphological and mechanical alterations in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs

Frontiers in Bioengineering and Biotechnology, 2023
Objectives: This study aimed to investigate the morphological and mechanical changes in articular cartilage and subchondral bone during spontaneous hip osteoarthritis in guinea pigs.Materials and methods: Hip joints of guinea pigs were investigated at 1,
Jiazi Gao, Pengling Ren, He Gong
doaj   +1 more source

Histomorphometric Quantitative Evaluation of Long-Term Risedronate Use in a Knee Osteoarthritis Rabbit Model

Frontiers in Veterinary Science, 2021
Osteoarthritis (OA) treatment is a major orthopedic challenge given that there is no ideal drug capable to reverse or stop the progression of the OA. In that regard, bisphosphonates have been proposed as potential disease-modifying drugs due to their ...
Silvia Fernández-Martín, Antonio González-Cantalapiedra, Antonio González-Cantalapiedra, María Permuy, Mario García-González, Mónica López-Peña, Mónica López-Peña, Fernando Muñoz, Fernando Muñoz   +8 more
doaj   +1 more source

Trabecular Bone Structure Correlates with Hand Posture and Use in Hominoids [PDF]

, 2013
Bone is capable of adapting during life in response to stress. Therefore, variation in locomotor and manipulative behaviours across extant hominoids may be reflected in differences in trabecular bone structure.
Smaers, JB, Tsegai, Zewdi J., Smaers, Jeroen B, Gross Thomas, Gross, T., Tsegai Zewdi J., Skinner Matthew M., Thomas Gross, Dieter H Pahr, Tsegai, Z. ; https://orcid.org/, Nguyen, N. Huynh, Skinner, M, Zewdi J. Tsegai (484661), Gross, T, Kivell, Tracy L., Zewdi J Tsegai, Pahr, D., Skinner, Matthew M, Skinner, M. ; https://orcid.org/, Matthew M Skinner, Pahr Dieter H., Kivell, T. ; https://orcid.org/, Kivell, TL, Nguyen, H., Smaers Jeroen B., Skinner, Matthew M., Tracy L. Kivell (484662), Kivell Tracy L., Nguyen N. Huynh, Nguyen, N Huynh, Gross, Thomas, Matthew M. Skinner (484667), Nguyen, NH, Jeroen B Smaers, Pahr, Dieter H, Tracy L Kivell, Thomas Gross (484663), N. Huynh Nguyen (484664), Dieter H. Pahr (484665), Pahr, Dieter H., Jeroen B. Smaers (484666), Tsegai, ZJ, Smaers, J., Pahr, DH, N Huynh Nguyen, Smaers, Jeroen B.   +45 more
core   +1 more source

A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes

Bone Reports, 2020
Objectives: The objective was to estimate the impact of the meniscus on cartilage and subchondral bone in knee osteoarthritis (OA). Methods: In a sample of 46 knee specimens (26 females), 13 (7 females) were classified as OA according to the Kellgren ...
G. Mitton, K. Engelke, S. Uk, J.D. Laredo, C. Chappard   +4 more
doaj   +1 more source

Magnetic resonance imaging evaluation of weight-bearing subchondral trabecular bone in the knee [PDF]

Skeletal Radiology, 2010
Changes in weight-bearing subchondral bone are central to osteoarthritis (OA) pathophysiology. Using MR, knee trabecular bone is typically assessed in the axial plane, however partial volume artifacts limit the utility of MR methods for femorotibial compartment subchondral bone analysis.
Erika, Schneider, Grace H, Lo, Gretchen, Sloane, Lynn, Fanella, David J, Hunter, Charles B, Eaton, Timothy E, McAlindon   +6 more
openaire   +2 more sources

Computed tomography-osteoabsorptiometry for assessing the density distribution of subchondral bone as a measure of long-term mechanical adaptation in individual joints [PDF]

, 1989
To estimate subchondral mineralisation patterns which represent the long-term loading history of individual joints, a method has been developed employing computed tomography (CT) which permits repeated examination of living joints.
Müller-Gerbl, Magdalena, Wimmer, Berthold, Hodapp, Norbert, Putz, Reinhard, Schulte, Erik   +4 more
core   +1 more source