Results 51 to 60 of about 558,914 (188)

Research subchronic toxicity TRIFLOS bird collection [PDF]

, 2018
Presents data on the subchronic toxicity of the new domestic cholagogue Triflos . Studies have shown that the examined cholagogue collection with repeated intragastric administration for 28 days in a thera-peutic dose, at the maximum daily dose and 20 ...
Tursunova, M.H, Abdurahmonova, N.А, Ibragimov, A.Ya   +2 more
core  

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

Acute and subchronic toxicity of the antitumor agent rhodium (II) citrate in Balb/c mice after intraperitoneal administration

Toxicology Reports, 2015
This study aimed to investigate potential acute and subchronic toxicity of rhodium (II) citrate in female Balb/c mice after intraperitoneal injections.
Marcella L.B. Carneiro, Cláudio A.P. Lopes, Ana L. Miranda-Vilela, Graziella A. Joanitti, Izabel C.R. da Silva, Márcia R. Mortari, Aparecido R. de Souza, Sônia N. Báo   +7 more
doaj   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Acute and subchronic oral toxicity of fermented Crescentia cujete (L) preparation in rats

Open Veterinary Journal
Background: Fermented Crescentia cujete L (FC-C) has significant potential as a multimodal therapeutic agent. However, its toxicological profile remains undefined and requires comprehensive elucidation.
Yos Adi Prakoso, Achmadi Susilo, Sitarina Widyarini, Oscar Maulana Pribadi, Paskalis Guntur Widya Mahendra   +4 more
doaj   +1 more source

Chlorfenapyr Induces Hepatotoxicity Associated With Oxidative Stress and Mitochondrial Dysfunction Involving Keap1/Nrf2 Signaling

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao, Jia Li, Cheng Li, Hua He, Lipu Deng   +4 more
wiley   +1 more source

Safety assessment of the Polypodium feei root extract: Acute and subchronic studies

Toxicology Reports, 2021
This study was performed to assess the safety of the oral acute and subchronic administration of Polypodium feei root extract through acute and subchronic studies in mice and rats, respectively.
Deden Winda Suwandi, Tina Rostinawati, Muchtaridi Muchtaridi, Anas Subarnas   +3 more
doaj   +1 more source

Hematological and Genotoxic Effects of Subchronic Oral Exposure to a Mancozeb‐Based Fungicide in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo, Natanael Vaz Crisóstomo Peixoto, Paula Soares Nakamura, Cecília Müller Wodzik, Lucas Ribeiro Maia dos Santos, Fábio Vieira de Andrade Borges, Lara Cândida de Sousa Machado, Jéssica Gardone Vitório, Renata Mazaro e Costa, Mônica Rodrigues Ferreira Machado, Walter Dias Júnior   +10 more
wiley   +1 more source

Stevia rebaudiana extract (main components: chlorogenic acid and its analogues) as a new safe feed additive: evaluation of acute toxicity, sub chronic toxicity, genotoxicity, and teratogenicity

Frontiers in Veterinary Science
IntroductionStevia rebaudiana extract (SREC), primarily composed of chlorogenic acid and its analogues, is a promising feed additive with potential benefits for livestock performance, gut health, and antioxidant capacity.
Yuting Li, Liping Zhu, Dongsheng He, Ling Fang, Yajing Li, Shusheng Tang   +5 more
doaj   +1 more source

Food consumption by male and female rats treated with JointAlive^® in 13-week subchronic toxicity study.

, 2023
Food consumption by male and female rats treated with JointAlive® in 13-week subchronic toxicity study.
Xin Li (51274), Shengcan Zou (17181432), Yuanyuan Wang (20181), Zimin Liu (10509550), Dehai Gao (17181435), Yanling Mu (4737747), Shanglong Wang (12045182), Jiancheng Zong (12045185), Li Li (14993)   +8 more
core   +1 more source