Results 61 to 70 of about 558,914 (188)

Low‐Dose Chlorothalonil Induces Testicular Injury Through Disruption of Steroidogenic Signaling in Adult Male Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Chlorothalonil (CHL) is a widely used organochlorine fungicide frequently detected in environmental and food matrices. Although increasing evidence indicates adverse effects in nontarget species, the mechanisms underlying CHL‐induced male reproductive toxicity remain incompletely understood.
Cristiana Livramento Oliveira Pinto, Nicoly Caixêta Gonçalves, Paula Rafaela Queiroz da Silva, Ludmila Rodrigues Pontes, Juliana Reis Machado, Virmondes Rodrigues Jr., Hugo Felix Perini, Gláucia Eloisa Munhoz de Lion Siervo   +7 more
wiley   +1 more source

Developmental toxic effects of ethylbenzene or toluene alone and in combination with butyl acetate in rats after inhalation exposure [PDF]

, 2007
First, the developmental toxic potential of n-butyl acetate (BA) was examined in Sprague-Dawley rats following whole body inhalation exposure, 6 h day-1, from day 6 to 20 of gestation, at concentrations of 0, 500, 1000, 2000 and 3000 ppm.
Bourges-Abella, Nathalie, Gallissot, Frédéric, Sabaté, Jean-Philippe, Muller, Samuel, Saillenfait, Anne-Marie   +4 more
core  

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source

Bisphenol M Induces Dose‐Dependent Hepatic Injury and Fibrotic Remodeling in Female Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The safety of bisphenol analogs as alternatives to bisphenol A (BPA) is increasingly concerning. This study investigated the hepatotoxic effects of bisphenol M (BPM), a widely used BPA substitute, in 6‐week‐old female BALB/c mice exposed to 2.5, 5, and 10 mg/kg/day intraperitoneally for 14 days. Hepatic changes were assessed via histopathology,
Muhammed Canik, Asuman Deveci Ozkan, Tuğba Kotil, Nazan Deniz Yön   +3 more
wiley   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Effects of Glyphosate and Glyphosate‐Based Herbicides on the Mammalian Gut Microbiome: A Critical Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Glyphosate has long been considered to pose negligible direct risk to mammals on the grounds that its molecular target, 5‐enolpyruvylshikimate‐3‐phosphate synthase (EPSPS), of the shikimate pathway, is absent from animal cells. This rationale is inaccurate as a complete toxicological argument, because the shikimate pathway is present in some ...
Robin Mesnage
wiley   +1 more source

A toxicological assessment of Ganoderma lucidum and Cordyceps militaris mushroom powders

Frontiers in Toxicology
Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C. militaris) are among the many mushrooms known for their long history of use in traditional medicine. Wildcrafted sources of mushrooms including G. lucidum and C.
Paola P. Chrysostomou, Elaine Freeman, Mary M. Murphy, Ankit Chaudhary, Nazia Siddiqui, Julie Daoust   +5 more
doaj   +1 more source

Evaluation of Preclinical Toxicity of Methanolic Extract of Sargassum tenerrimum using the Zebrafish Model [PDF]

Journal of Clinical and Diagnostic Research
Introduction: In the field of biomedicine, marine algae have gained significant attention due to the abundance of bioactive compounds they contain. However, studies on the chronic toxicity of algae are limited.
Raman Yadav, Punnagai Kumaravelu, Subburaya Umamaheswari, Viswanathan Subramanian, Suvarna Jyoti Kantipudi   +4 more
doaj   +1 more source

Safety pharmacology and subchronic toxicity of jinqing granules in rats

, 2017
Background Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease.
Yuanli Zhang, Gang Ye, Qi Dong, Qiji Liu, Yinglun Li, Yuanling Xiao, Qian Rong, Ling Zhao, Kaisheng Yu, Min Xu, Xiaoyu Yang, Helin Chen, Fei Shi, Xuerong Zhou, Cheng Lv   +14 more
core   +1 more source

Human‐Centered Monitoring of Asphalt Emissions: Linking Exposure, Climate, and Health

Safety Science and Technology, EarlyView.
A human‐centered framework linking heat‐driven asphalt emissions to real‐world exposure, biological response, and functional health outcomes, highlighting how climate‐sensitive infrastructure can become a measurable, manageable source of urban environmental and health risk. ABSTRACT Urban infrastructure shapes environmental quality not only through its
Suliman Rashid, Hessam Yazdani, Jessica Verpeut, Shiva Pooladvand, Vajiheh Akbarzadeh, Ali Shamshiripour, Elham H. Fini   +6 more
wiley   +1 more source