Results 71 to 80 of about 558,914 (188)

Acute and subchronic toxicity analysis of surface modified paclitaxel attached hydroxyapatite and titanium dioxide nanoparticles

, 2015
Gopinath Devanand Venkatasubbu,1 S Ramasamy,2 Pramod Reddy Gaddam,3 J Kumar2 1Department of Biotechnology, University of Madras, Chennai, Tamil Nadu, India; 2Crystal Growth Centre, Anna University, Chennai, Tamil Nadu, India; 3Department of Pharmacology,
Gaddam PR, Kumar J, Ramasamy S, Venkatasubbu GD   +3 more
core  

Synergistic Toxicity of Low‐Concentration Metal Mixture on Male Rats: Reproductive, Renal, and Hepatic Effects

Environmental Toxicology, EarlyView.
ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida, Thalita Tofanin Sargiani D'Assumpção, Ana Priscila Gomes Silva, Carolina Rocha Moreira de Oliveira, Tailisi Hoppe Trevizani, Rubens Cesar Lopes Figueira, Lucas Buruaem Moreira, Juliana Elaine Perobelli   +7 more
wiley   +1 more source

Acute and Subchronic Toxicity Study of Tud-Rak-Ka-Sai-Puu Recipe in Rats [PDF]

, 2012
Acute and subchronic toxicities of Tud-Rak-Ka-Sai-Puu (TR) recipe were studied in male and female rats. After 14 days of a single oral administration of test substance (5,000 mg/kg body weight), measurement of the body and organs weights, necropsy and ...
Termwiset, P, Subcharoen, Pennapa, Srithiwong, S, Srithiwong, Supachai, Termwiset, Pornthip, Jaijoy, K, Jaijoy, Kanjana, Subcharoen, P, Tungsukruthai, P, Vannasiri, Supaporn, Vannasiri, S, Tungsukruthai, Parunkul, Chiruntanat, N, Chuthaputti, Anchalee, Sireeratawong, Seewaboon, Sireeratawong, S, Nanna, U, Chuthaputti, A, Nanna, Urarat, Chiruntanat, Natthakarn   +19 more
core   +1 more source

Climate‐Modulated Particle Toxicity: Acute Exposure to an Environmentally Informed Microplastic Mixture Induces Sex‐Dependent Systemic Reorganization in Swiss Mice

Environmental Toxicology, EarlyView.
ABSTRACT Microplastic (MP) pollution is widely recognized as an emerging environmental threat. Yet, most studies still rely on controlled experimental conditions that poorly reflect environmental complexity, potentially underestimating risks under realistic scenarios, particularly during short‐term exposures. Here, we tested whether acute oral exposure
Guilherme Malafaia, Rafaela Ribeiro de Brito, Aline Sueli de Lima de Rodrigues, Omar Cruz Santiago, Andrés Hugo Arias, Thiarlen Marinho da Luz   +5 more
wiley   +1 more source

Comparison of points of departure between subchronic and chronic toxicity studies on food additives, food contaminants and natural food constituents

, 2020
In the past, it was generally accepted as a default assumption that No-Observed-Adverse-Effect Levels (NOAELs) or Lowest-Observed-Adverse-Effect Levels (LOAELs) in long-term toxicity studies are lower than in short-term ones, i.e.
Guth, Sabine, Lachenmeier, Dirk W., Hüser, Stephanie, Leist, Marcel, Diel, Patrick, Cartus, Alexander T., Baum, Matthias, Roth, Angelika, Engeli, Barbara, Zarn, Jürg   +9 more
core   +1 more source

Investigation of the Protective Effect of Morin on Oxidative Stress and Apoptosis in Malathion‐Induced Hepatotoxicity in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Malathion (MAL) is a widely used organophosphate pesticide associated with hepatotoxicity through oxidative stress and apoptosis. Morin, a naturally occurring flavonoid, exhibits potent antioxidant and anti‐inflammatory properties. This study investigated oxidative stress, inflammatory, and apoptotic alterations induced by acute and subacute ...
Seval Yılmaz, Eda İ. Demirbağ, Hakan Bağ, Ali O. Çeribaşı   +3 more
wiley   +1 more source

In vitro characterization and in vivo toxicity, antioxidant and immunomodulatory effect of fermented foods; Xeniji™

BMC Complementary and Alternative Medicine, 2017
Background Xeniji, produced by fermenting various types of foods with lactic acid bacteria and yeast, has been commonly consumed as functional food. However, nutrition value, bioactivities and safety of different fermented products maybe varies.
Noraisyah Zulkawi, Kam Heng Ng, Rizi Zamberi, Swee Keong Yeap, Dilan Satharasinghe, Indu Bala Jaganath, Anisah Binti Jamaluddin, Sheau Wei Tan, Wan Yong Ho, Noorjahan Banu Alitheen, Kamariah Long   +10 more
doaj   +1 more source

A Biweekly GLP‐1R Agonist Designed With Drug‐Free Intervals for Enhanced Efficacy, Receptor Homeostasis and Gastrointestinal Tolerability

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding, Qing Liu, Qiong Luo, Xiaojun Yao, Xingxing Fan   +4 more
wiley   +1 more source

Safety evaluation of the venom from scorpion Rhopalurus junceus: assessment of oral short term, subchronic toxicity and teratogenic effect

, 2020
Plot data of the manuscript Safety evaluation of the venom from scorpion Rhopalurus junceus: assessment of oral short term, subchronic toxicity and teratogenic ...
Lagarto, A (via Mendeley Data)
core   +2 more sources

Pharmaco-toxicological Assessment of Antiparasitic Drug for Dogs and Cats "Gelmintal Mini Syrup"

Российский паразитологический журнал, 2020
The purpose of the research is conducting pharmaco-toxicological assessment of Gelmintal Mini Syrup based on a combination of moxidectin and toltrazuril. Materials and methods. The study was carried out on 64 white male rats and 40 white mice.
G. B. Arisova, M. V. Arisov, I. A. Stepanova, V. V. Khristenko   +3 more
doaj   +1 more source