Results 21 to 30 of about 82,598 (315)

Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability function approach and in vivo pharmacokinetic study

Drug Delivery, 2021
Flibanserin (FLB) was approved by FDA for the treatment of pre-menopausal female hypoactive sexual desire disorder (HSDD). FLB suffers from low oral bioavailability (33%) which might be due to hepatic first-pass metabolism in addition to its poor aqueous
Marianne J. Naguib, Amal I. A. Makhlouf
doaj   +1 more source

A survey of drug liking and cravings in patients using sublingual or intranasal ketamine for treatment resistant depression: A preliminary evaluation of real world addictive potential

Frontiers in Psychiatry, 2022
Ketamine has gained rapid popularity as a treatment option for treatment resistant depression (TRD). Though seen only in limited contexts, ketamine is a potential drug of abuse, addiction and diversion.
Brittany Chubbs, Jay Wang, Shaina Archer, Carson Chrenek, Atul Khullar, Michael Wolowyk, Jennifer Swainson   +6 more
doaj   +1 more source

Compliance with allergen immunotherapy and factors affecting compliance among patients with respiratory allergies

Human Vaccines & Immunotherapeutics, 2017
Background: Allergen-specific immunotherapy (AIT) is safe and effective for the treatment of allergic rhinitis and allergic asthma. However, patient non-compliance is a major barrier to achieving optimal outcomes Objective: To determine the level of ...
Fardous Musa, Mona Al-Ahmad, Nermina Arifhodzic, Waleed Al-Herz   +3 more
doaj   +1 more source

ALLERGEN IMMUNOTHERAPY: EFFICACY, PERSISTENCE, CONSISTENCY, AND COST EFFECTIVENESS

RUDN Journal of Medicine, 2018
Although allergen immunotherapy (AIT) has been used for the treatment of allergic rhinitis (AR), allergic conjunctivitis, asthma, stinging insect hypersensitivity, and atopic dermatitis for over 100 years, it has been slow to gain universal acceptance ...
Dana Wallace
doaj   +1 more source

Fast Dissolving Sublingual Strips: A Novel Approach for the Delivery of Isosorbide Dinitrate [PDF]

Pharmaceutical Sciences, 2019
Background: Isosorbide dinitrate (ISDN) is used for treating the angina attacks. In addition, oral ISDN is available in immediate and sustained release formulations and the bioavailability of ISDN is about 20-25% when taken orally.
Marzieh Fathei, Mitra Alami-milani, Sara Salatin, Sharahm Sattari, Hassan Montazam, Farhad Fekrat, Mitra Jelvehgari   +6 more
doaj   +1 more source

Preclinical Safety and Pharmacokinetics of Heat Stable Oxytocin in Sublingual Fast-Dissolving Tablet Formulation

Pharmaceutics, 2022
The work reported here focuses on an evaluation of a novel heat stable formulation of a uterotonic peptide drug oxytocin involving stability testing under elevated temperatures and toxicokinetic response generated by sublingual (SL) administration in ...
Changcheng Zhu, Manjari Lal
doaj   +1 more source

Beyond the pill: New medication delivery options for ADHD [PDF]

, 2017
Successful treatment of pediatric disorders has necessitated the development of alternative medication formulations, as children may prefer alternative dosage forms to tablets or capsules.
Cutler, Andrew J, Mattingly, Gregory W
core   +2 more sources

Acceptability of a Sublingual Drug Formulation for Respiratory Tract Infections in Children Aged 3 to 5 Years

Pharmaceutics, 2021
In pediatrics, acceptability has emerged as a key factor for compliance, and consequently for treatment safety and efficacy. Polyvalent mechanical bacterial lysate (PMBL) in 50-mg sublingual tablets is indicated in children and adults for the prophylaxis
Andrzej Emeryk, Thibault Vallet, Ewelina Wawryk-Gawda, Arkadiusz Jędrzejewski, Frederic Durmont, Fabrice Ruiz   +5 more
doaj   +1 more source

Single high-dose buprenorphine for opioid craving during withdrawal. [PDF]

, 2018
BackgroundOpioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a ...
Ahmadi, Jamshid, Ghahremani, Dara, Jahromi, Mina Sefidfard, London, Edythe D   +3 more
core   +2 more sources

Misoprostol en dos formas de administración para la dilatación cervical en el aborto instrumentado

Medimay, 2013
Introducción: el misoprostol es un producto extremadamente útil como fármaco abortivo, tiene un alto margen de seguridad cuando es pautado en dosis adecuadas y con una correcta supervisión médica.
Luis Gustavo García Baños, Marilín Alonso Sicilia, Elibet Concepción Pérez   +2 more
doaj   +4 more sources