Results 151 to 160 of about 676,730 (305)

Inflammatory compounds: neuropeptide substance P and cytokines

, 2009
Inflammatory diseases represent one of the major causes of morbidity and mortality throughout the world and they affect the functions of several tissues.
Ciampoli C, De Lutiis MA, Felaco P, Theoharides TC, Castellani ML, ANTINOLFI, PIERLUIGI, Perrella A, Pandolfi F, Vecchiet J, Tetè S, Cuccurullo C, Conti F, ShaikYB, CERULLI, Giuliano Giorgio, CARAFFA, Auro, Salini V, De Amicis D, Kempuraj D   +17 more
core  

Initial Validation of a Computerized Adaptive Test for Substance Use Disorder Identification in Adolescents

Purpose: Computerized adaptive tests (CATs) are highly efficient assessment tools that couple low patient and clinician time burden with high diagnostic accuracy.
Marriott, Brigid R., Hulvershorn, Leslie A., Smoker, Michael P., Aalsma, Matthew C., Adams, Zachary W., Gibbons, Robert D.   +5 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Pirt promotes substance P release in cancer-induced bone pain. [PDF]

Pain Rep
Cheng X, Zhang Z, Zhou L, Zeng J, Jiang C, Cheng S, Zhou Y, Yu G, Wang C.   +8 more
europepmc   +1 more source

Societal Response to Developmental Differences and Adolescent Substance Abuse Treatment Outcomes

, 2002
Recent findings indicate an increased concern that conventional substance abuse treatment models consistently reflect less than satisfactory outcomes when applied to adolescents.
Osborne, Randall R.
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Function of Substance P and Substance P Receptor in Exercise

International Journal of Applied Physics and Mathematics, 2013
Dan Xu, Xiyan Xie, Shun Li, Jimin Zhang, Lijuan Hou   +4 more
openaire   +1 more source

Mast Cells and Substance P: Neuroinflammatory Loops at the Molecular and Translational Clinical Levels. [PDF]

Biomolecules
Aitella E, Bruno M, Azzellino G, De Martinis M, Ginaldi L, Romano C.   +5 more
europepmc   +1 more source

Personality of mothers of substance-dependent patients

, 2010
David Baron1, Samir AbolMagd2, Salwa Erfan2, Mona El Rakhawy21Temple University School of Medicine, Philadelphia, PA, USA; 2University of Cairo School of Medicine, Cairo, EgyptAbstract: Drug addicts often come from dysfunctional families.
David Baron, Salwa Erfan, Samir AbolMagd, et al   +3 more
core