Results 161 to 170 of about 676,730 (305)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Effects of olopatadine hydrochloride on substance P concentrations in nasal secretions and nasal symptoms. [PDF]

World J Exp Med
Katagiri F, Hatoyama-Tanaka S, Watanabe T, Takayanagi R, Suzuki M, Yamada Y.   +5 more
europepmc   +1 more source

Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

, 2014
Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National ...
La WG, Park H, Jeong GJ, Kim BS, Jin M, Yoon HH, Bhang SH, Park S, Char K   +8 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ferrocenyl-Substituted Curcumin Derivatives as Potential SHP‑2 Inhibitors for Anticolorectal Cancer: Design, Synthesis and In Vitro Evaluation

ACS Omega
Xing-Ze Zhang, Gen Li, Gao-Yong Hu, Chen-Lin Wang, Yu-Qiu Fang, Yuye Li, Xue-Jie Qi, Lili Duan   +7 more
doaj   +1 more source

Salivary Substance P Levels During Cesarean Section Under Spinal versus General Anesthesia: A Prospective Study. [PDF]

J Pain Res
Alhowary AA, Altal O, Bani Hani D, Alrusan A, Hulliel AF, Jadallah RK, Alshaykh R, Dabash TY, Al Sharie AH, Al Hazaymeh M.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Substance P-expressing neurons in the hypothalamic paraventricular nucleus mediate chronic cough hypersensitivity via the hypothalamus-airway neural pathway. [PDF]

Front Neurosci
Zhang X, Chen J, Lin C, Xiao T, Wu B, He F.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone-Producing Adenomas. [PDF]

J Am Heart Assoc
Lopez AG, Duparc C, Renouf S, D'Agostino M, De Sousa K, Amar L, Defortescu G, Manceau G, Sabourin JC, Fernandes-Rosa FL, Zennaro MC, Meatchi T, Nicolas G, Louiset E, Lefebvre H.   +14 more
europepmc   +1 more source